Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside

Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but othe...

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Detalles Bibliográficos
Autores principales: Hebert, Jessica F., Burfeind, Kevin G., Malinoski, Darren, Hutchens, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831947/
https://www.ncbi.nlm.nih.gov/pubmed/36644345
http://dx.doi.org/10.1016/j.ekir.2022.09.026
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author Hebert, Jessica F.
Burfeind, Kevin G.
Malinoski, Darren
Hutchens, Michael P.
author_facet Hebert, Jessica F.
Burfeind, Kevin G.
Malinoski, Darren
Hutchens, Michael P.
author_sort Hebert, Jessica F.
collection PubMed
description Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but other potential therapies, including pretreatments for those at risk for developing RIAKI, are under investigation. This review outlines the mechanisms and clinical significance of RIAKI, investigational treatments and their specific targets, and the status of ongoing research trials.
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spelling pubmed-98319472023-01-12 Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside Hebert, Jessica F. Burfeind, Kevin G. Malinoski, Darren Hutchens, Michael P. Kidney Int Rep Review Rhabdomyolysis-induced acute kidney injury (RIAKI) occurs following damage to the muscular sarcolemma sheath, resulting in the leakage of myoglobin and other metabolites that cause kidney damage. Currently, the sole recommended clinical treatment for RIAKI is aggressive fluid resuscitation, but other potential therapies, including pretreatments for those at risk for developing RIAKI, are under investigation. This review outlines the mechanisms and clinical significance of RIAKI, investigational treatments and their specific targets, and the status of ongoing research trials. Elsevier 2022-09-30 /pmc/articles/PMC9831947/ /pubmed/36644345 http://dx.doi.org/10.1016/j.ekir.2022.09.026 Text en © 2022 International Society of Nephrology. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Hebert, Jessica F.
Burfeind, Kevin G.
Malinoski, Darren
Hutchens, Michael P.
Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside
title Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside
title_full Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside
title_fullStr Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside
title_full_unstemmed Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside
title_short Molecular Mechanisms of Rhabdomyolysis-Induced Kidney Injury: From Bench to Bedside
title_sort molecular mechanisms of rhabdomyolysis-induced kidney injury: from bench to bedside
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831947/
https://www.ncbi.nlm.nih.gov/pubmed/36644345
http://dx.doi.org/10.1016/j.ekir.2022.09.026
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