From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins

Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C....

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Autor principal: Aktories, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831965/
https://www.ncbi.nlm.nih.gov/pubmed/36203094
http://dx.doi.org/10.1007/s00210-022-02300-9
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author Aktories, Klaus
author_facet Aktories, Klaus
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description Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. difficile toxin research are presented with the focus on toxin B (TcdB), covering toxin structure, receptor binding, toxin up-take and refolding, the intracellular actions of TcdB, and the treatment of C. difficile infection.
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spelling pubmed-98319652023-01-12 From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins Aktories, Klaus Naunyn Schmiedebergs Arch Pharmacol Review Selected findings about Clostridioides difficile (formerly Clostridium difficile) toxins are presented in a narrative review. Starting with a personal view on research about G proteins, adenylyl cyclase, and ADP-ribosylating toxins in the laboratory of Günter Schultz in Heidelberg, milestones of C. difficile toxin research are presented with the focus on toxin B (TcdB), covering toxin structure, receptor binding, toxin up-take and refolding, the intracellular actions of TcdB, and the treatment of C. difficile infection. Springer Berlin Heidelberg 2022-10-07 2023 /pmc/articles/PMC9831965/ /pubmed/36203094 http://dx.doi.org/10.1007/s00210-022-02300-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Aktories, Klaus
From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins
title From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins
title_full From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins
title_fullStr From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins
title_full_unstemmed From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins
title_short From signal transduction to protein toxins—a narrative review about milestones on the research route of C. difficile toxins
title_sort from signal transduction to protein toxins—a narrative review about milestones on the research route of c. difficile toxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9831965/
https://www.ncbi.nlm.nih.gov/pubmed/36203094
http://dx.doi.org/10.1007/s00210-022-02300-9
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