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Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging charac...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832004/ https://www.ncbi.nlm.nih.gov/pubmed/36627270 http://dx.doi.org/10.1038/s41467-022-35535-4 |
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author | McCafferty, Cian Gruenbaum, Benjamin F. Tung, Renee Li, Jing-Jing Zheng, Xinyuan Salvino, Peter Vincent, Peter Kratochvil, Zachary Ryu, Jun Hwan Khalaf, Aya Swift, Kohl Akbari, Rashid Islam, Wasif Antwi, Prince Johnson, Emily A. Vitkovskiy, Petr Sampognaro, James Freedman, Isaac G. Kundishora, Adam Depaulis, Antoine David, François Crunelli, Vincenzo Sanganahalli, Basavaraju G. Herman, Peter Hyder, Fahmeed Blumenfeld, Hal |
author_facet | McCafferty, Cian Gruenbaum, Benjamin F. Tung, Renee Li, Jing-Jing Zheng, Xinyuan Salvino, Peter Vincent, Peter Kratochvil, Zachary Ryu, Jun Hwan Khalaf, Aya Swift, Kohl Akbari, Rashid Islam, Wasif Antwi, Prince Johnson, Emily A. Vitkovskiy, Petr Sampognaro, James Freedman, Isaac G. Kundishora, Adam Depaulis, Antoine David, François Crunelli, Vincenzo Sanganahalli, Basavaraju G. Herman, Peter Hyder, Fahmeed Blumenfeld, Hal |
author_sort | McCafferty, Cian |
collection | PubMed |
description | Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging characteristics of human absence seizures. Neuronally, seizures feature overall decreased but rhythmic firing of neurons in cortex and thalamus. Individual cortical and thalamic neurons express one of four distinct patterns of seizure-associated activity, one of which causes a transient initial peak in overall firing at seizure onset, and another which drives sustained decreases in overall firing. 40–60 s before seizure onset there begins a decline in low frequency electroencephalographic activity, neuronal firing, and behavior, but an increase in higher frequency electroencephalography and rhythmicity of neuronal firing. Our findings demonstrate that prolonged brain state changes precede consciousness-impairing seizures, and that during seizures distinct functional groups of cortical and thalamic neurons produce an overall transient firing increase followed by a sustained firing decrease, and increased rhythmicity. |
format | Online Article Text |
id | pubmed-9832004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-98320042023-01-12 Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures McCafferty, Cian Gruenbaum, Benjamin F. Tung, Renee Li, Jing-Jing Zheng, Xinyuan Salvino, Peter Vincent, Peter Kratochvil, Zachary Ryu, Jun Hwan Khalaf, Aya Swift, Kohl Akbari, Rashid Islam, Wasif Antwi, Prince Johnson, Emily A. Vitkovskiy, Petr Sampognaro, James Freedman, Isaac G. Kundishora, Adam Depaulis, Antoine David, François Crunelli, Vincenzo Sanganahalli, Basavaraju G. Herman, Peter Hyder, Fahmeed Blumenfeld, Hal Nat Commun Article Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging characteristics of human absence seizures. Neuronally, seizures feature overall decreased but rhythmic firing of neurons in cortex and thalamus. Individual cortical and thalamic neurons express one of four distinct patterns of seizure-associated activity, one of which causes a transient initial peak in overall firing at seizure onset, and another which drives sustained decreases in overall firing. 40–60 s before seizure onset there begins a decline in low frequency electroencephalographic activity, neuronal firing, and behavior, but an increase in higher frequency electroencephalography and rhythmicity of neuronal firing. Our findings demonstrate that prolonged brain state changes precede consciousness-impairing seizures, and that during seizures distinct functional groups of cortical and thalamic neurons produce an overall transient firing increase followed by a sustained firing decrease, and increased rhythmicity. Nature Publishing Group UK 2023-01-10 /pmc/articles/PMC9832004/ /pubmed/36627270 http://dx.doi.org/10.1038/s41467-022-35535-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article McCafferty, Cian Gruenbaum, Benjamin F. Tung, Renee Li, Jing-Jing Zheng, Xinyuan Salvino, Peter Vincent, Peter Kratochvil, Zachary Ryu, Jun Hwan Khalaf, Aya Swift, Kohl Akbari, Rashid Islam, Wasif Antwi, Prince Johnson, Emily A. Vitkovskiy, Petr Sampognaro, James Freedman, Isaac G. Kundishora, Adam Depaulis, Antoine David, François Crunelli, Vincenzo Sanganahalli, Basavaraju G. Herman, Peter Hyder, Fahmeed Blumenfeld, Hal Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
title | Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
title_full | Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
title_fullStr | Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
title_full_unstemmed | Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
title_short | Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
title_sort | decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832004/ https://www.ncbi.nlm.nih.gov/pubmed/36627270 http://dx.doi.org/10.1038/s41467-022-35535-4 |
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