Oxidative stress-triggered Wnt signaling perturbation characterizes the tipping point of lung adeno-to-squamous transdifferentiation

Lkb1 deficiency confers the Kras-mutant lung cancer with strong plasticity and the potential for adeno-to-squamous transdifferentiation (AST). However, it remains largely unknown how Lkb1 deficiency dynamically regulates AST. Using the classical AST mouse model (Kras (LSL-G12D/+);Lkb1(flox/flox), KL...

Descripción completa

Detalles Bibliográficos
Autores principales: Fang, Zhaoyuan, Han, Xiangkun, Chen, Yueqing, Tong, Xinyuan, Xue, Yun, Yao, Shun, Tang, Shijie, Pan, Yunjian, Sun, Yihua, Wang, Xue, Jin, Yujuan, Chen, Haiquan, Hu, Liang, Hui, Lijian, Li, Lin, Chen, Luonan, Ji, Hongbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832009/
https://www.ncbi.nlm.nih.gov/pubmed/36627278
http://dx.doi.org/10.1038/s41392-022-01227-0

Ejemplares similares

Ejemplares similares