Age-related matrix stiffening epigenetically regulates α-Klotho expression and compromises chondrocyte integrity

Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age-related biophysical alterations are poorly understood. Here, we show that epigenetic regulation of α-Klotho represent...

Descripción completa

Detalles Bibliográficos
Autores principales: Iijima, Hirotaka, Gilmer, Gabrielle, Wang, Kai, Bean, Allison C., He, Yuchen, Lin, Hang, Tang, Wan-Yee, Lamont, Daniel, Tai, Chia, Ito, Akira, Jones, Jeffrey J., Evans, Christopher, Ambrosio, Fabrisia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832042/
https://www.ncbi.nlm.nih.gov/pubmed/36627269
http://dx.doi.org/10.1038/s41467-022-35359-2

Ejemplares similares

Ejemplares similares