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Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging
PURPOSE: We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside ([18F]FAZA), for tumor hypoxia detection and to assess the correlation of hypoxic kinetic parameters with static imaging measures in canine spontaneous tumors....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832187/ https://www.ncbi.nlm.nih.gov/pubmed/36643946 http://dx.doi.org/10.1007/s13139-022-00780-4 |
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author | Choen, Sangkyung Kent, Michael S. Chaudhari, Abhijit J. Cherry, Simon R. Krtolica, Ana Zwingenberger, Allison L. |
author_facet | Choen, Sangkyung Kent, Michael S. Chaudhari, Abhijit J. Cherry, Simon R. Krtolica, Ana Zwingenberger, Allison L. |
author_sort | Choen, Sangkyung |
collection | PubMed |
description | PURPOSE: We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside ([18F]FAZA), for tumor hypoxia detection and to assess the correlation of hypoxic kinetic parameters with static imaging measures in canine spontaneous tumors. METHODS: Sixteen dogs with spontaneous tumors underwent a 150-min dynamic PET scan using either [18F]FMISO or [18F]FAZA. The maximum tumor-to-muscle ratio (TMR(max)) > 1.4 on the last image frame was used as the standard threshold to determine tumor hypoxia. The tumor time-activity curves were analyzed using irreversible and reversible two-tissue compartment models and graphical methods. TMR(max) was compared with radiotracer trapping rate (k(3)), influx rate (K(i)), and distribution volume (V(T)). RESULTS: Tumor hypoxia was detected in 7/8 tumors in the [18F]FMISO group and 4/8 tumors in the [18F]FAZA group. All hypoxic tumors were detected at > 120 min with [18F]FMISO and at > 60 min with [18F]FAZA. [18F]FAZA showed better fit with the reversible model. TMR(max) was strongly correlated with the irreversible parameters (k(3) and K(i)) for [18F]FMISO at > 90 min and with the reversible parameter (V(T)) for [18F]FAZA at > 120 min. CONCLUSIONS: Our results showed that [18F]FAZA provided a promising alternative radiotracer to [18F]FMISO with detecting the presence of tumor hypoxia at an earlier time (60 min), consistent with its favorable faster kinetics. The strong correlation between TMR(max) over the 90–150 min and 120–150 min timeframes with [18F]FMISO and [18F]FAZA, respectively, with kinetic parameters associated with tumor hypoxia for each radiotracer, suggests that a static scan measurement (TMR(max)) is a good alternative to quantify tumor hypoxia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13139-022-00780-4. |
format | Online Article Text |
id | pubmed-9832187 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-98321872023-01-12 Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging Choen, Sangkyung Kent, Michael S. Chaudhari, Abhijit J. Cherry, Simon R. Krtolica, Ana Zwingenberger, Allison L. Nucl Med Mol Imaging Original Article PURPOSE: We evaluated the kinetics of the hypoxia PET radiotracers, [18F]fluoromisonidazole ([18F]FMISO) and [18F]fluoroazomycin-arabinoside ([18F]FAZA), for tumor hypoxia detection and to assess the correlation of hypoxic kinetic parameters with static imaging measures in canine spontaneous tumors. METHODS: Sixteen dogs with spontaneous tumors underwent a 150-min dynamic PET scan using either [18F]FMISO or [18F]FAZA. The maximum tumor-to-muscle ratio (TMR(max)) > 1.4 on the last image frame was used as the standard threshold to determine tumor hypoxia. The tumor time-activity curves were analyzed using irreversible and reversible two-tissue compartment models and graphical methods. TMR(max) was compared with radiotracer trapping rate (k(3)), influx rate (K(i)), and distribution volume (V(T)). RESULTS: Tumor hypoxia was detected in 7/8 tumors in the [18F]FMISO group and 4/8 tumors in the [18F]FAZA group. All hypoxic tumors were detected at > 120 min with [18F]FMISO and at > 60 min with [18F]FAZA. [18F]FAZA showed better fit with the reversible model. TMR(max) was strongly correlated with the irreversible parameters (k(3) and K(i)) for [18F]FMISO at > 90 min and with the reversible parameter (V(T)) for [18F]FAZA at > 120 min. CONCLUSIONS: Our results showed that [18F]FAZA provided a promising alternative radiotracer to [18F]FMISO with detecting the presence of tumor hypoxia at an earlier time (60 min), consistent with its favorable faster kinetics. The strong correlation between TMR(max) over the 90–150 min and 120–150 min timeframes with [18F]FMISO and [18F]FAZA, respectively, with kinetic parameters associated with tumor hypoxia for each radiotracer, suggests that a static scan measurement (TMR(max)) is a good alternative to quantify tumor hypoxia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13139-022-00780-4. Springer Nature Singapore 2022-10-11 2023-02 /pmc/articles/PMC9832187/ /pubmed/36643946 http://dx.doi.org/10.1007/s13139-022-00780-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Choen, Sangkyung Kent, Michael S. Chaudhari, Abhijit J. Cherry, Simon R. Krtolica, Ana Zwingenberger, Allison L. Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging |
title | Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging |
title_full | Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging |
title_fullStr | Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging |
title_full_unstemmed | Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging |
title_short | Kinetic Evaluation of the Hypoxia Radiotracers [(18)F]FMISO and [(18)F]FAZA in Dogs with Spontaneous Tumors Using Dynamic PET/CT Imaging |
title_sort | kinetic evaluation of the hypoxia radiotracers [(18)f]fmiso and [(18)f]faza in dogs with spontaneous tumors using dynamic pet/ct imaging |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832187/ https://www.ncbi.nlm.nih.gov/pubmed/36643946 http://dx.doi.org/10.1007/s13139-022-00780-4 |
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