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Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

Expression of the HIV-1 genome by RNA Polymerase II is regulated at multiple steps, as are most cellular genes, including recruitment of general transcription factors and control of transcriptional elongation from the core promoter. We recently discovered that tripartite motif protein TRIM24 is recr...

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Detalles Bibliográficos
Autores principales: Horvath, Riley M., Brumme, Zabrina L., Sadowski, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832417/
https://www.ncbi.nlm.nih.gov/pubmed/36631514
http://dx.doi.org/10.1038/s41598-023-27765-3