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Regulation of 5‐fluorodeoxyuridine monophosphate‐thymidylate synthase ternary complex levels by autophagy confers resistance to 5‐fluorouracil

5‐Fluorouracil (5‐FU) is a cornerstone drug used to treat colorectal cancer (CRC). However, the prolonged exposure of CRC cells to 5‐FU results in acquired resistance. We have previously demonstrated that levels of the 5‐fluorodeoxyuridylate (FdUMP) covalent complex with thymidylate synthase (FdUMP‐...

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Detalles Bibliográficos
Autores principales:	Nishizawa, Nana, Kurasaka, Chinatsu, Ogino, Yoko, Sato, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832531/ https://www.ncbi.nlm.nih.gov/pubmed/36643896 http://dx.doi.org/10.1096/fba.2022-00099

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