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SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma

The spermatogenesis associated serine rich 2 (SPATS2) is a member of RNA-binding protein in which the abnormal expression is linked with carcinogenesis in serval types of cancer. However, there is no systematic study on the differential expression, prognostic significance, epigenetic regulation, imm...

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Autores principales: Lin, Jing, Yan, Jia, Deng, Xiu ling, Wang, Chang shan, Wang, Hai sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832668/
https://www.ncbi.nlm.nih.gov/pubmed/36631750
http://dx.doi.org/10.1186/s12876-022-02633-y
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author Lin, Jing
Yan, Jia
Deng, Xiu ling
Wang, Chang shan
Wang, Hai sheng
author_facet Lin, Jing
Yan, Jia
Deng, Xiu ling
Wang, Chang shan
Wang, Hai sheng
author_sort Lin, Jing
collection PubMed
description The spermatogenesis associated serine rich 2 (SPATS2) is a member of RNA-binding protein in which the abnormal expression is linked with carcinogenesis in serval types of cancer. However, there is no systematic study on the differential expression, prognostic significance, epigenetic regulation, immune infiltration of SPATS2 in hepatocellular carcinoma (HCC). In the present study, we investigated the expression, prognosis, epigenetic regulation, and immune cell infiltration of SPATS2 in HCC. We found that the elevated expression of SPATS2 was unfavorably associated with the clinical pathological stage and prognosis. Functional enrichment analysis revealed that SPATS2 is associated with cell cycle, apoptosis and cancer cell metastasis processes in HCC. Our results confirmed that knockdown of SPATS2 will affect cell cycle, apoptosis and invasion of HCC cell lines. Moreover, the expression of SPATS2 is upregulated by epigenetic regulation, including DNA methylation, m6A and histone modification in HCC. In addition, SPATS2 expression was positively correlated with immune cell infiltration or expression of immune related gene markers in HCC. Taken together, our data demonstrated that SPATS2 is associated with progression and immune infiltration, and could serve as a prognostic biomarker for HCC. In conclusion, these results highlight the potential of SPATS2 to be used as a therapeutic target for HCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02633-y.
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spelling pubmed-98326682023-01-12 SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma Lin, Jing Yan, Jia Deng, Xiu ling Wang, Chang shan Wang, Hai sheng BMC Gastroenterol Research The spermatogenesis associated serine rich 2 (SPATS2) is a member of RNA-binding protein in which the abnormal expression is linked with carcinogenesis in serval types of cancer. However, there is no systematic study on the differential expression, prognostic significance, epigenetic regulation, immune infiltration of SPATS2 in hepatocellular carcinoma (HCC). In the present study, we investigated the expression, prognosis, epigenetic regulation, and immune cell infiltration of SPATS2 in HCC. We found that the elevated expression of SPATS2 was unfavorably associated with the clinical pathological stage and prognosis. Functional enrichment analysis revealed that SPATS2 is associated with cell cycle, apoptosis and cancer cell metastasis processes in HCC. Our results confirmed that knockdown of SPATS2 will affect cell cycle, apoptosis and invasion of HCC cell lines. Moreover, the expression of SPATS2 is upregulated by epigenetic regulation, including DNA methylation, m6A and histone modification in HCC. In addition, SPATS2 expression was positively correlated with immune cell infiltration or expression of immune related gene markers in HCC. Taken together, our data demonstrated that SPATS2 is associated with progression and immune infiltration, and could serve as a prognostic biomarker for HCC. In conclusion, these results highlight the potential of SPATS2 to be used as a therapeutic target for HCC. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-022-02633-y. BioMed Central 2023-01-11 /pmc/articles/PMC9832668/ /pubmed/36631750 http://dx.doi.org/10.1186/s12876-022-02633-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lin, Jing
Yan, Jia
Deng, Xiu ling
Wang, Chang shan
Wang, Hai sheng
SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
title SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
title_full SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
title_fullStr SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
title_full_unstemmed SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
title_short SPATS2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
title_sort spats2 is correlated with cell cycle progression and immune cells infiltration in hepatocellular carcinoma
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832668/
https://www.ncbi.nlm.nih.gov/pubmed/36631750
http://dx.doi.org/10.1186/s12876-022-02633-y
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