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Sequre: a high-performance framework for secure multiparty computation enables biomedical data sharing

Secure multiparty computation (MPC) is a cryptographic tool that allows computation on top of sensitive biomedical data without revealing private information to the involved entities. Here, we introduce Sequre, an easy-to-use, high-performance framework for developing performant MPC applications. Se...

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Detalles Bibliográficos
Autores principales: Smajlović, Haris, Shajii, Ariya, Berger, Bonnie, Cho, Hyunghoon, Numanagić, Ibrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832703/
https://www.ncbi.nlm.nih.gov/pubmed/36631897
http://dx.doi.org/10.1186/s13059-022-02841-5
Descripción
Sumario:Secure multiparty computation (MPC) is a cryptographic tool that allows computation on top of sensitive biomedical data without revealing private information to the involved entities. Here, we introduce Sequre, an easy-to-use, high-performance framework for developing performant MPC applications. Sequre offers a set of automatic compile-time optimizations that significantly improve the performance of MPC applications and incorporates the syntax of Python programming language to facilitate rapid application development. We demonstrate its usability and performance on various bioinformatics tasks showing up to 3–4 times increased speed over the existing pipelines with 7-fold reductions in codebase sizes. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13059-022-02841-5.