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ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe

ERCC1/XPF is a heterodimeric DNA endonuclease critical for repair of certain chemotherapeutic agents. We recently identified that ERCC1- and p53-deficient lung cancer cells are tolerant to platinum-based chemotherapy. ATR inhibition synergistically re-stored platinum sensitivity to platinum tolerant...

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Detalles Bibliográficos
Autores principales:	Heyza, Joshua R, Ekinci, Elmira, Lindquist, Jacob, Lei, Wen, Yunker, Christopher, Vinothkumar, Vilvanathan, Rowbotham, Rachelle, Polin, Lisa, Snider, Natalie G, Van Buren, Eric, Watza, Donovan, Back, Jessica B, Chen, Wei, Mamdani, Hirva, Schwartz, Ann G, Turchi, John J, Bepler, Gerold, Patrick, Steve M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	DNA Damage Sensing and Repair
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832712/ https://www.ncbi.nlm.nih.gov/pubmed/36644397 http://dx.doi.org/10.1093/narcan/zcac045

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