IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

Inosine monophosphate dehydrogenase (IMPDH) is a rate‐limiting enzyme in de novo guanine nucleotide synthesis pathway. Although IMPDH inhibitors are widely used as effective immunosuppressants, their antitumor effects have not been proven in the clinical setting. Here, we found that acute myeloid le...

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Detalles Bibliográficos
Autores principales: Liu, Xiaoxiao, Sato, Naru, Yabushita, Tomohiro, Li, Jingmei, Jia, Yuhan, Tamura, Moe, Asada, Shuhei, Fujino, Takeshi, Fukushima, Tsuyoshi, Yonezawa, Taishi, Tanaka, Yosuke, Fukuyama, Tomofusa, Tsuchiya, Akiho, Shikata, Shiori, Iwamura, Hiroyuki, Kinouchi, Chieko, Komatsu, Kensuke, Yamasaki, Satoshi, Shibata, Tatsuhiro, Sasaki, Atsuo T, Schibler, Janet, Wunderlich, Mark, O'Brien, Eric, Mizukawa, Benjamin, Mulloy, James C, Sugiura, Yuki, Takizawa, Hitoshi, Shibata, Takuma, Miyake, Kensuke, Kitamura, Toshio, Goyama, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832838/
https://www.ncbi.nlm.nih.gov/pubmed/36453131
http://dx.doi.org/10.15252/emmm.202115631

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