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Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016

After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify speci...

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Autores principales: Kayiwa, John T., Mayanja, Martin N., Nakayiki, Teddy Muwawu, Senfuka, Fred, Mugga, Julius, Koehler, Jeffrey W., Mossel, Eric C., Lutwama, Julius J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833084/
https://www.ncbi.nlm.nih.gov/pubmed/36410326
http://dx.doi.org/10.4269/ajtmh.22-0481
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author Kayiwa, John T.
Mayanja, Martin N.
Nakayiki, Teddy Muwawu
Senfuka, Fred
Mugga, Julius
Koehler, Jeffrey W.
Mossel, Eric C.
Lutwama, Julius J.
author_facet Kayiwa, John T.
Mayanja, Martin N.
Nakayiki, Teddy Muwawu
Senfuka, Fred
Mugga, Julius
Koehler, Jeffrey W.
Mossel, Eric C.
Lutwama, Julius J.
author_sort Kayiwa, John T.
collection PubMed
description After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify species most likely involved in Rift Valley fever virus transmission. This information could be used to forecast risk and facilitate improvement of prevention and response tools for use in preventing or controlling future outbreaks. From these collections, two virus isolates were obtained, one each from a pool of Aedes tricholabis and Ae. gibbinsi. Next-generation sequencing identified both isolates as Wesselsbron virus, family Flaviviridae, a neglected arbovirus of economic importance. These are the first reported Wesselsbron virus isolates from Uganda since 1966.
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spelling pubmed-98330842023-01-17 Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016 Kayiwa, John T. Mayanja, Martin N. Nakayiki, Teddy Muwawu Senfuka, Fred Mugga, Julius Koehler, Jeffrey W. Mossel, Eric C. Lutwama, Julius J. Am J Trop Med Hyg Short Report After confirmation of two human cases of Rift Valley fever (RVF) in March 2016 in the Kabale district of Uganda, an entomological investigation was conducted with a focus on mosquito species composition and abundance of known and potential mosquito vector species, and virus testing to identify species most likely involved in Rift Valley fever virus transmission. This information could be used to forecast risk and facilitate improvement of prevention and response tools for use in preventing or controlling future outbreaks. From these collections, two virus isolates were obtained, one each from a pool of Aedes tricholabis and Ae. gibbinsi. Next-generation sequencing identified both isolates as Wesselsbron virus, family Flaviviridae, a neglected arbovirus of economic importance. These are the first reported Wesselsbron virus isolates from Uganda since 1966. The American Society of Tropical Medicine and Hygiene 2023-01 2022-11-21 /pmc/articles/PMC9833084/ /pubmed/36410326 http://dx.doi.org/10.4269/ajtmh.22-0481 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Short Report
Kayiwa, John T.
Mayanja, Martin N.
Nakayiki, Teddy Muwawu
Senfuka, Fred
Mugga, Julius
Koehler, Jeffrey W.
Mossel, Eric C.
Lutwama, Julius J.
Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016
title Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016
title_full Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016
title_fullStr Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016
title_full_unstemmed Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016
title_short Phylogenetic Analysis of Wesselsbron Virus Isolated from Field-Captured Mosquitoes during a Rift Valley Fever Outbreak in Kabale District, Uganda—2016
title_sort phylogenetic analysis of wesselsbron virus isolated from field-captured mosquitoes during a rift valley fever outbreak in kabale district, uganda—2016
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833084/
https://www.ncbi.nlm.nih.gov/pubmed/36410326
http://dx.doi.org/10.4269/ajtmh.22-0481
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