Cargando…

Novel protein-truncating variant in the APOB gene may protect from coronary artery disease and adverse cardiovascular events

BACKGROUND AND AIMS: Genetic testing is still rarely used for the diagnosis of dyslipidemia, even though gene variants determining plasma lipids levels are not uncommon. METHODS: Starting from a a pilot-analysis of targeted Next Generation Sequencing (NGS) of 5 genes related to familial hypercholest...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mango, Gabriele, Osti, Nicola, Udali, Silvia, Vareschi, Anna, Malerba, Giovanni, Giorgetti, Alejandro, Pizzolo, Francesca, Friso, Simonetta, Girelli, Domenico, Olivieri, Oliviero, Castagna, Annalisa, Martinelli, Nicola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833228/ https://www.ncbi.nlm.nih.gov/pubmed/36644201 http://dx.doi.org/10.1016/j.athplu.2022.06.001

Ejemplares similares

Urinary extracellular vesicles carry valuable hints through mRNA for the understanding of endocrine hypertension
por: Friso, Simonetta, et al.
Publicado: (2023)

Not Just Arterial Damage: Increased Incidence of Venous Thromboembolic Events in Cardiovascular Patients With Elevated Plasma Levels of Apolipoprotein CIII
por: Olivieri, Oliviero, et al.
Publicado: (2019)

High Plasma Concentration of Apolipoprotein C-III Confers an Increased Risk of Cerebral Ischemic Events on Cardiovascular Patients Anticoagulated With Warfarin
por: Olivieri, Oliviero, et al.
Publicado: (2022)

Basophil Blood Cell Count Is Associated With Enhanced Factor II Plasma Coagulant Activity and Increased Risk of Mortality in Patients With Stable Coronary Artery Disease: Not Only Neutrophils as Prognostic Marker in Ischemic Heart Disease
por: Pizzolo, Francesca, et al.
Publicado: (2021)

Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension
por: De Santis, Domenica, et al.
Publicado: (2021)

Factor II Activity is Similarly Increased in Patients With Elevated Apolipoprotein CIII and in Carriers of the Factor II 20210A Allele
por: Olivieri, Oliviero, et al.
Publicado: (2013)

Low Levels of Serum Paraoxonase Activities are Characteristic of Metabolic Syndrome and May Influence the Metabolic-Syndrome-Related Risk of Coronary Artery Disease
por: Martinelli, Nicola, et al.
Publicado: (2012)

High Plasma Levels of Activated Factor VII-Antithrombin Complex Point to Increased Tissue Factor Expression in Patients with SARS-CoV-2 Pneumonia: A Potential Link with COVID-19 Prothrombotic Diathesis
por: Martinelli, Nicola, et al.
Publicado: (2022)

Trace Elements Status and Metallothioneins DNA Methylation Influence Human Hepatocellular Carcinoma Survival Rate
por: Udali, Silvia, et al.
Publicado: (2021)

The RFC1 80G>A, among Common One-Carbon Polymorphisms, Relates to Survival Rate According to DNA Global Methylation in Primary Liver Cancers
por: Moruzzi, Sara, et al.
Publicado: (2016)

Case Report: Microangiopathic Hemolytic Anemia With Normal ADAMTS13 Activity
por: Osti, Nicola, et al.
Publicado: (2021)

Evaluation of Hepcidin Isoforms in Hemodialysis Patients by a Proteomic Approach Based on SELDI-TOF MS
por: Campostrini, Natascia, et al.
Publicado: (2010)

Hyperhomocysteinemia and Mortality after Coronary Artery Bypass Grafting
por: Girelli, Domenico, et al.
Publicado: (2006)

Additive effect of LRP8/APOER2 R952Q variant to APOE ε2/ε3/ε4 genotype in modulating apolipoprotein E concentration and the risk of myocardial infarction: a case-control study
por: Martinelli, Nicola, et al.
Publicado: (2009)

Proteomic analysis of urinary extracellular vesicles highlights specific signatures for patients with primary aldosteronism
por: Bertolone, Lorenzo, et al.
Publicado: (2023)

Combined Effect of Hemostatic Gene Polymorphisms and the Risk of Myocardial Infarction in Patients with Advanced Coronary Atherosclerosis
por: Martinelli, Nicola, et al.
Publicado: (2008)

One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation
por: Moruzzi, Sara, et al.
Publicado: (2017)

Deep vein thrombosis in SARS-CoV-2 pneumonia-affected patients within standard care units: Exploring a submerged portion of the iceberg
por: Pizzolo, Francesca, et al.
Publicado: (2020)

A Novel ALAS2 Missense Mutation in Two Brothers With Iron Overload and Associated Alterations in Serum Hepcidin/Erythroferrone Levels
por: Lira Zidanes, Acaynne, et al.
Publicado: (2020)

Gene sequence variations of the platelet P2Y12 receptor are associated with coronary artery disease
por: Cavallari, Ugo, et al.
Publicado: (2007)

Serum levels of the hepcidin-20 isoform in a large general population: The Val Borbera study()
por: Campostrini, Natascia, et al.
Publicado: (2012)

Access Rate to the Emergency Department for Venous Thromboembolism in Relationship with Coarse and Fine Particulate Matter Air Pollution
por: Martinelli, Nicola, et al.
Publicado: (2012)

A relative ADAMTS13 deficiency supports the presence of a secondary microangiopathy in COVID 19
por: Martinelli, Nicola, et al.
Publicado: (2020)

Lifestyle and dietary factors, iron status and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a Transfusion Medicine Unit: a cross-sectional study
por: Bortolus, Renata, et al.
Publicado: (2023)

CD14(+)-Monocytes Exposed to Apolipoprotein CIII Express Tissue Factor
por: Olivieri, Oliviero, et al.
Publicado: (2023)

Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study
por: Martinelli, Nicola, et al.
Publicado: (2012)

Correction: Increased Serum Hepcidin Levels in Subjects with the Metabolic Syndrome: A Population Study
por: Martinelli, Nicola, et al.
Publicado: (2013)

High resolution preparation of monocyte-derived macrophages (MDM) protein fractions for clinical proteomics
por: Polati, Rita, et al.
Publicado: (2009)

DNA Methylation and Hydroxymethylation in Primary Colon Cancer and Synchronous Hepatic Metastasis
por: Udali, Silvia, et al.
Publicado: (2018)

B vitamin blood concentrations and one-carbon metabolism polymorphisms in a sample of Italian women and men attending a unit of transfusion medicine: a cross-sectional study
por: Bortolus, Renata, et al.
Publicado: (2020)

Clinical risk scores for the early prediction of severe outcomes in patients hospitalized for COVID-19
por: Ageno, Walter, et al.
Publicado: (2021)

Red Blood Cell Morphologic Abnormalities in Patients Hospitalized for COVID-19
por: Marchi, Giacomo, et al.
Publicado: (2022)

Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease
por: Peloso, Gina M., et al.
Publicado: (2019)

DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma
por: Udali, Silvia, et al.
Publicado: (2015)

Hepcidin Levels and Their Determinants in Different Types of Myelodysplastic Syndromes
por: Santini, Valeria, et al.
Publicado: (2011)

Anemia and Iron Deficiency in Cancer Patients: Role of Iron Replacement Therapy
por: Busti, Fabiana, et al.
Publicado: (2018)

Iron deficiency in the elderly population, revisited in the hepcidin era
por: Busti, Fabiana, et al.
Publicado: (2014)

Investigation of human apoB48 metabolism using a new, integrated non‐steady‐state model of apoB48 and apoB100 kinetics
por: Björnson, E., et al.
Publicado: (2019)

Aceruloplasminemia: A Severe Neurodegenerative Disorder Deserving an Early Diagnosis
por: Marchi, Giacomo, et al.
Publicado: (2019)

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
por: Khoo, Bernard, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_uut5qgsj97tg029oetkqmkg5n9