Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile

Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an ant...

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Autores principales: Lupo, Maria Giovanna, Arcidiacono, Diletta, Zaramella, Alice, Fimiani, Fabio, Calabrò, Paolo, Cefalù, Angelo Baldassare, Averna, Maurizio, D'Erasmo, Laura, Arca, Marcello, De Martin, Sara, Zambon, Alberto, Ferri, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833247/
https://www.ncbi.nlm.nih.gov/pubmed/36644506
http://dx.doi.org/10.1016/j.athplu.2021.05.001
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author Lupo, Maria Giovanna
Arcidiacono, Diletta
Zaramella, Alice
Fimiani, Fabio
Calabrò, Paolo
Cefalù, Angelo Baldassare
Averna, Maurizio
D'Erasmo, Laura
Arca, Marcello
De Martin, Sara
Zambon, Alberto
Ferri, Nicola
author_facet Lupo, Maria Giovanna
Arcidiacono, Diletta
Zaramella, Alice
Fimiani, Fabio
Calabrò, Paolo
Cefalù, Angelo Baldassare
Averna, Maurizio
D'Erasmo, Laura
Arca, Marcello
De Martin, Sara
Zambon, Alberto
Ferri, Nicola
author_sort Lupo, Maria Giovanna
collection PubMed
description Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect.
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spelling pubmed-98332472023-01-12 Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile Lupo, Maria Giovanna Arcidiacono, Diletta Zaramella, Alice Fimiani, Fabio Calabrò, Paolo Cefalù, Angelo Baldassare Averna, Maurizio D'Erasmo, Laura Arca, Marcello De Martin, Sara Zambon, Alberto Ferri, Nicola Atheroscler Plus Article Lomitapide, a drug for the treatment of homozygous familial hypercholesterolemia patients, reduced total and LDL cholesterol but no significant changes were observed on PCSK9 and Lp(a) plasma levels. Some changes of inflammatory mediators were also observed, including hsCRP, which may suggest an anti-inflammatory effect. Elsevier 2021-06-19 /pmc/articles/PMC9833247/ /pubmed/36644506 http://dx.doi.org/10.1016/j.athplu.2021.05.001 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Lupo, Maria Giovanna
Arcidiacono, Diletta
Zaramella, Alice
Fimiani, Fabio
Calabrò, Paolo
Cefalù, Angelo Baldassare
Averna, Maurizio
D'Erasmo, Laura
Arca, Marcello
De Martin, Sara
Zambon, Alberto
Ferri, Nicola
Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile
title Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile
title_full Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile
title_fullStr Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile
title_full_unstemmed Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile
title_short Lomitapide does not alter PCSK9 and Lp(a) levels in homozygous familial hypercholesterolemia patients: Analysis on cytokines and lipid profile
title_sort lomitapide does not alter pcsk9 and lp(a) levels in homozygous familial hypercholesterolemia patients: analysis on cytokines and lipid profile
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833247/
https://www.ncbi.nlm.nih.gov/pubmed/36644506
http://dx.doi.org/10.1016/j.athplu.2021.05.001
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