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Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults

BACKGROUND AND AIMS: The role of Helicobacter pylori (H. pylori) infection in carotid atherosclerosis remains inconsistent and sometimes controversial. We aimed to determine whether H. pylori infection is associated with carotid atherosclerotic plaques in a large number of Chinese adults. METHODS: W...

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Autores principales: Du, Li, Liu, Jianghong, Jin, Cheng, Ma, Yuan, Yin, Linlin, Man, Sailimai, Li, Shijun, Li, Liming, Ning, Yi, Zhang, Xinghu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833265/
https://www.ncbi.nlm.nih.gov/pubmed/36644666
http://dx.doi.org/10.1016/j.athplu.2021.08.004
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author Du, Li
Liu, Jianghong
Jin, Cheng
Ma, Yuan
Yin, Linlin
Man, Sailimai
Li, Shijun
Li, Liming
Ning, Yi
Zhang, Xinghu
author_facet Du, Li
Liu, Jianghong
Jin, Cheng
Ma, Yuan
Yin, Linlin
Man, Sailimai
Li, Shijun
Li, Liming
Ning, Yi
Zhang, Xinghu
author_sort Du, Li
collection PubMed
description BACKGROUND AND AIMS: The role of Helicobacter pylori (H. pylori) infection in carotid atherosclerosis remains inconsistent and sometimes controversial. We aimed to determine whether H. pylori infection is associated with carotid atherosclerotic plaques in a large number of Chinese adults. METHODS: We recruited 108,210 Chinese adults who participated in a standard medical screening with both carotid ultrasonic examination and (13)C-urea breath test for H.pylori infection from two Chinese cohorts. A total of 93,915 adults were included in the analysis after excluding participants with cardiovascular disease (CVD) and carotid plaques at baseline. Hazard ratio (HR) for developing carotid plaques by H. pylori infection was analyzed using the Cox proportional hazard model, with sociodemographic and clinical factors adjusted. Findings across cohorts were pooled by meta-analyses. RESULTS: 11,208 (13.13%) participants occurred carotid plaques at a median follow-up of 20 months in the MN cohort, while 1279 (14.95%) participants occurred carotid plaques at a median follow-up of 24 months in the MJ cohort. Compare with participants without H. pylori infection, participants with H. pylori infection were more likely to occur carotid plaques. After adjusting for age, sex, annual personal income, body mass index, blood pressure, blood glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and estimated glomerular filtration rate, the HR was 1.04 (95%CI: 1.01–1.08). After further adjusting for education level, marital status, smoking status, alcohol drinking status, physical activity, and family history of CVD, the HR changed minimally. Additional sensitivity analyses confirmed the robustness of the results. Significant interactions of age, sex, blood pressure, blood glucose, or chronic inflammation were not observed in this research. CONCLUSIONS: H. pylori infection was associated with carotid plaque onset in a large number of Chinese adults without previous CVD. These data suggested that the prevention of H. pylori infection may reduce the burden of carotid atherosclerosis.
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spelling pubmed-98332652023-01-12 Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults Du, Li Liu, Jianghong Jin, Cheng Ma, Yuan Yin, Linlin Man, Sailimai Li, Shijun Li, Liming Ning, Yi Zhang, Xinghu Atheroscler Plus Article BACKGROUND AND AIMS: The role of Helicobacter pylori (H. pylori) infection in carotid atherosclerosis remains inconsistent and sometimes controversial. We aimed to determine whether H. pylori infection is associated with carotid atherosclerotic plaques in a large number of Chinese adults. METHODS: We recruited 108,210 Chinese adults who participated in a standard medical screening with both carotid ultrasonic examination and (13)C-urea breath test for H.pylori infection from two Chinese cohorts. A total of 93,915 adults were included in the analysis after excluding participants with cardiovascular disease (CVD) and carotid plaques at baseline. Hazard ratio (HR) for developing carotid plaques by H. pylori infection was analyzed using the Cox proportional hazard model, with sociodemographic and clinical factors adjusted. Findings across cohorts were pooled by meta-analyses. RESULTS: 11,208 (13.13%) participants occurred carotid plaques at a median follow-up of 20 months in the MN cohort, while 1279 (14.95%) participants occurred carotid plaques at a median follow-up of 24 months in the MJ cohort. Compare with participants without H. pylori infection, participants with H. pylori infection were more likely to occur carotid plaques. After adjusting for age, sex, annual personal income, body mass index, blood pressure, blood glucose, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, high-sensitivity C-reactive protein, and estimated glomerular filtration rate, the HR was 1.04 (95%CI: 1.01–1.08). After further adjusting for education level, marital status, smoking status, alcohol drinking status, physical activity, and family history of CVD, the HR changed minimally. Additional sensitivity analyses confirmed the robustness of the results. Significant interactions of age, sex, blood pressure, blood glucose, or chronic inflammation were not observed in this research. CONCLUSIONS: H. pylori infection was associated with carotid plaque onset in a large number of Chinese adults without previous CVD. These data suggested that the prevention of H. pylori infection may reduce the burden of carotid atherosclerosis. Elsevier 2021-08-13 /pmc/articles/PMC9833265/ /pubmed/36644666 http://dx.doi.org/10.1016/j.athplu.2021.08.004 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Du, Li
Liu, Jianghong
Jin, Cheng
Ma, Yuan
Yin, Linlin
Man, Sailimai
Li, Shijun
Li, Liming
Ning, Yi
Zhang, Xinghu
Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults
title Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults
title_full Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults
title_fullStr Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults
title_full_unstemmed Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults
title_short Association between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults
title_sort association between helicobacter pylori infection and carotid atherosclerosis in chinese adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833265/
https://www.ncbi.nlm.nih.gov/pubmed/36644666
http://dx.doi.org/10.1016/j.athplu.2021.08.004
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