Peptide-guided lipid nanoparticles deliver mRNA to the neural retina of rodents and nonhuman primates

Lipid nanoparticle (LNP)–based mRNA delivery holds promise for the treatment of inherited retinal degenerations. Currently, LNP-mediated mRNA delivery is restricted to the retinal pigment epithelium (RPE) and Müller glia. LNPs must overcome ocular barriers to transfect neuronal cells critical for vi...

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Detalles Bibliográficos
Autores principales: Herrera-Barrera, Marco, Ryals, Renee C., Gautam, Milan, Jozic, Antony, Landry, Madeleine, Korzun, Tetiana, Gupta, Mohit, Acosta, Chris, Stoddard, Jonathan, Reynaga, Rene, Tschetter, Wayne, Jacomino, Nick, Taratula, Oleh, Sun, Conroy, Lauer, Andreas K., Neuringer, Martha, Sahay, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833661/
https://www.ncbi.nlm.nih.gov/pubmed/36630502
http://dx.doi.org/10.1126/sciadv.add4623

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