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Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences

Early experience with food influences taste preference in adulthood. How gustatory experience influences development of taste preferences and refinement of cortical circuits has not been investigated. Here, we exposed weanling mice to an array of taste solutions and determined the effects on the pre...

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Autores principales: Schiff, Hillary C., Kogan, Joshua F., Isaac, Maria, Czarnecki, Lindsey A., Fontanini, Alfredo, Maffei, Arianna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833665/
https://www.ncbi.nlm.nih.gov/pubmed/36630501
http://dx.doi.org/10.1126/sciadv.ade6561
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author Schiff, Hillary C.
Kogan, Joshua F.
Isaac, Maria
Czarnecki, Lindsey A.
Fontanini, Alfredo
Maffei, Arianna
author_facet Schiff, Hillary C.
Kogan, Joshua F.
Isaac, Maria
Czarnecki, Lindsey A.
Fontanini, Alfredo
Maffei, Arianna
author_sort Schiff, Hillary C.
collection PubMed
description Early experience with food influences taste preference in adulthood. How gustatory experience influences development of taste preferences and refinement of cortical circuits has not been investigated. Here, we exposed weanling mice to an array of taste solutions and determined the effects on the preference for sweet in adulthood. We demonstrate an experience-dependent shift in sucrose preference persisting several weeks following the termination of exposure. A shift in sucrose palatability, altered neural responsiveness to sucrose, and inhibitory synaptic plasticity in the gustatory portion of the insular cortex (GC) were also induced. The modulation of sweet preference occurred within a restricted developmental window, but restoration of the capacity for inhibitory plasticity in adult GC reactivated the sensitivity of sucrose preference to taste experience. Our results establish a fundamental link between gustatory experience, sweet preference, inhibitory plasticity, and cortical circuit function and highlight the importance of early life nutrition in setting taste preferences.
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spelling pubmed-98336652023-01-18 Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences Schiff, Hillary C. Kogan, Joshua F. Isaac, Maria Czarnecki, Lindsey A. Fontanini, Alfredo Maffei, Arianna Sci Adv Neuroscience Early experience with food influences taste preference in adulthood. How gustatory experience influences development of taste preferences and refinement of cortical circuits has not been investigated. Here, we exposed weanling mice to an array of taste solutions and determined the effects on the preference for sweet in adulthood. We demonstrate an experience-dependent shift in sucrose preference persisting several weeks following the termination of exposure. A shift in sucrose palatability, altered neural responsiveness to sucrose, and inhibitory synaptic plasticity in the gustatory portion of the insular cortex (GC) were also induced. The modulation of sweet preference occurred within a restricted developmental window, but restoration of the capacity for inhibitory plasticity in adult GC reactivated the sensitivity of sucrose preference to taste experience. Our results establish a fundamental link between gustatory experience, sweet preference, inhibitory plasticity, and cortical circuit function and highlight the importance of early life nutrition in setting taste preferences. American Association for the Advancement of Science 2023-01-11 /pmc/articles/PMC9833665/ /pubmed/36630501 http://dx.doi.org/10.1126/sciadv.ade6561 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Schiff, Hillary C.
Kogan, Joshua F.
Isaac, Maria
Czarnecki, Lindsey A.
Fontanini, Alfredo
Maffei, Arianna
Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
title Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
title_full Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
title_fullStr Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
title_full_unstemmed Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
title_short Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
title_sort experience-dependent plasticity of gustatory insular cortex circuits and taste preferences
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833665/
https://www.ncbi.nlm.nih.gov/pubmed/36630501
http://dx.doi.org/10.1126/sciadv.ade6561
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