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Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation

Longevity is a defining, heritable trait that varies dramatically between species. To resolve the genetic regulation of this trait, we have mined genomic variation in rockfishes, which range in longevity from 11 to over 205 years. Multiple shifts in rockfish longevity have occurred independently and...

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Autores principales: Treaster, Stephen, Deelen, Joris, Daane, Jacob M., Murabito, Joanne, Karasik, David, Harris, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833670/
https://www.ncbi.nlm.nih.gov/pubmed/36630509
http://dx.doi.org/10.1126/sciadv.add2743
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author Treaster, Stephen
Deelen, Joris
Daane, Jacob M.
Murabito, Joanne
Karasik, David
Harris, Matthew P.
author_facet Treaster, Stephen
Deelen, Joris
Daane, Jacob M.
Murabito, Joanne
Karasik, David
Harris, Matthew P.
author_sort Treaster, Stephen
collection PubMed
description Longevity is a defining, heritable trait that varies dramatically between species. To resolve the genetic regulation of this trait, we have mined genomic variation in rockfishes, which range in longevity from 11 to over 205 years. Multiple shifts in rockfish longevity have occurred independently and in a short evolutionary time frame, thus empowering convergence analyses. Our analyses reveal a common network of genes under convergent evolution, encompassing established aging regulators such as insulin signaling, yet also identify flavonoid (aryl-hydrocarbon) metabolism as a pathway modulating longevity. The selective pressures on these pathways indicate the ancestral state of rockfishes was long lived and that the changes in short-lived lineages are adaptive. These pathways were also used to explore genome-wide association studies of human longevity, identifying the aryl-hydrocarbon metabolism pathway to be significantly associated with human survival to the 99th percentile. This evolutionary intersection defines and cross-validates a previously unappreciated genetic architecture that associates with the evolution of longevity across vertebrates.
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spelling pubmed-98336702023-01-18 Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation Treaster, Stephen Deelen, Joris Daane, Jacob M. Murabito, Joanne Karasik, David Harris, Matthew P. Sci Adv Biomedicine and Life Sciences Longevity is a defining, heritable trait that varies dramatically between species. To resolve the genetic regulation of this trait, we have mined genomic variation in rockfishes, which range in longevity from 11 to over 205 years. Multiple shifts in rockfish longevity have occurred independently and in a short evolutionary time frame, thus empowering convergence analyses. Our analyses reveal a common network of genes under convergent evolution, encompassing established aging regulators such as insulin signaling, yet also identify flavonoid (aryl-hydrocarbon) metabolism as a pathway modulating longevity. The selective pressures on these pathways indicate the ancestral state of rockfishes was long lived and that the changes in short-lived lineages are adaptive. These pathways were also used to explore genome-wide association studies of human longevity, identifying the aryl-hydrocarbon metabolism pathway to be significantly associated with human survival to the 99th percentile. This evolutionary intersection defines and cross-validates a previously unappreciated genetic architecture that associates with the evolution of longevity across vertebrates. American Association for the Advancement of Science 2023-01-11 /pmc/articles/PMC9833670/ /pubmed/36630509 http://dx.doi.org/10.1126/sciadv.add2743 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Treaster, Stephen
Deelen, Joris
Daane, Jacob M.
Murabito, Joanne
Karasik, David
Harris, Matthew P.
Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
title Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
title_full Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
title_fullStr Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
title_full_unstemmed Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
title_short Convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
title_sort convergent genomics of longevity in rockfishes highlights the genetics of human life span variation
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833670/
https://www.ncbi.nlm.nih.gov/pubmed/36630509
http://dx.doi.org/10.1126/sciadv.add2743
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