Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification

The expression of a mutant Lamin A, progerin, in Hutchinson-Gilford Progeria Syndrome leads to alterations in genome architecture, nuclear morphology, epigenetic states, and altered phenotypes in all cells of the mesenchymal lineage. Here, we report a comprehensive analysis of the transcriptional st...

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Detalles Bibliográficos
Autores principales: San Martin, Rebeca, Das, Priyojit, Sanders, Jacob T, Hill, Ashtyn M, McCord, Rachel Patton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833827/
https://www.ncbi.nlm.nih.gov/pubmed/36579892
http://dx.doi.org/10.7554/eLife.81290

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