Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance

Patients affected by colorectal cancer (CRC) with DNA mismatch repair deficiency (MMRd), often respond to immune checkpoint blockade therapies, while those with mismatch repair-proficient (MMRp) tumors generally do not. Interestingly, a subset of MMRp CRCs contains variable fractions of MMRd cells,...

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Detalles Bibliográficos
Autores principales: Amodio, Vito, Lamba, Simona, Chilà, Rosaria, Cattaneo, Chiara M., Mussolin, Benedetta, Corti, Giorgio, Rospo, Giuseppe, Berrino, Enrico, Tripodo, Claudio, Pisati, Federica, Bartolini, Alice, Aquilano, Maria Costanza, Marsoni, Silvia, Mauri, Gianluca, Marchiò, Caterina, Abrignani, Sergio, Di Nicolantonio, Federica, Germano, Giovanni, Bardelli, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833846/
https://www.ncbi.nlm.nih.gov/pubmed/36584674
http://dx.doi.org/10.1016/j.ccell.2022.12.003

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