MiR-100 rs1834306 A>G Increases Biliary Atresia Risk in Southern Han Chinese Children

BACKGROUND: Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. miR-100 plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single-nucleotide polymorphism in miR-100 has been proven to modulate susceptibili...

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Detalles Bibliográficos
Autores principales: Chang, Jiaming, Liang, Jiankun, Chai, Chengwei, Liu, Fei, Tao, Boyuan, Wang, Hezhen, Tong, Yanlu, Wang, Zhe, Xia, Huimin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9833893/
https://www.ncbi.nlm.nih.gov/pubmed/36644163
http://dx.doi.org/10.1155/2023/4835839
Descripción
Sumario:BACKGROUND: Biliary atresia (BA) is a type of severe cholestatic childhood disease that may have a genetic component. miR-100 plays a key role in regulating cell apoptosis, proliferation, and inflammatory reactions. A single-nucleotide polymorphism in miR-100 has been proven to modulate susceptibility to various diseases. METHODS: We conducted a case-control retrospective study to explore the correlation between miR-100 gene polymorphism (rs1834306 A>G) and biliary atresia susceptibility in 484 Chinese patients and 1445 matched control subjects. RESULTS: Our results showed that rs1834306 A>G was correlated with a significantly increased risk for BA (GG vs. AA: adjusted odds ratio (OR) = 1.44, 95%confidence interval (CI) = 1.02–2.03, p = 0.041; and GG vs. AA/AG: adjusted OR = 1.39, 95%CI = 1.02–1.89, p = 0.036). CONCLUSIONS: Our results showed that the rs1834306 A>G polymorphism is associated with an increased risk for BA and contributes to BA susceptibility.

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