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Structural basis of broad-spectrum β-lactam resistance in Staphylococcus aureus

Broad-spectrum β-lactam antibiotic resistance in Staphylococcus aureus is a global healthcare burden(1,2). In clinical strains, resistance is largely controlled by BlaR1(3), a receptor that senses β-lactams through the acylation of its sensor domain, inducing transmembrane signalling and activation...

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Detalles Bibliográficos
Autores principales:	Alexander, J. Andrew N., Worrall, Liam J., Hu, Jinhong, Vuckovic, Marija, Satishkumar, Nidhi, Poon, Raymond, Sobhanifar, Solmaz, Rosell, Federico I., Jenkins, Joshua, Chiang, Daniel, Mosimann, Wesley A., Chambers, Henry F., Paetzel, Mark, Chatterjee, Som S., Strynadka, Natalie C. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834060/ https://www.ncbi.nlm.nih.gov/pubmed/36599987 http://dx.doi.org/10.1038/s41586-022-05583-3

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