Pevonedistat, a Nedd8-activating enzyme inhibitor, in combination with ibrutinib in patients with relapsed/refractory B-cell non-Hodgkin lymphoma

Pevonedistat (TAK924) is a Nedd8-activating enzyme inhibitor with preclinical activity in non-Hodgkin lymphoma (NHL). This open-label, Phase I, multicenter, investigator-sponsored study enrolled patients with relapsed/refractory (R/R) NHL and chronic lymphocytic leukemia (CLL). The primary objective...

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Detalles Bibliográficos
Autores principales: Torka, Pallawi, Kambhampati, Swetha, Chen, Lu, Wang, Xiaoguang, Chen, Canping, Vuong, Dan, Qin, Hanjun, Muir, Alexandra, Orand, Kirsten, Borja, Ivana, Lynne Smith, D., Herrera, Alex F., Spurgeon, Stephen E. F., Park, Byung, Lewis, Lionel D., Hernandez-Ilizaliturri, Francisco, Xia, Zheng, Danilov, Alexey V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834208/
https://www.ncbi.nlm.nih.gov/pubmed/36631449
http://dx.doi.org/10.1038/s41408-022-00763-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834208/
https://www.ncbi.nlm.nih.gov/pubmed/36631449
http://dx.doi.org/10.1038/s41408-022-00763-w

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