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Single-nuclei transcriptomics enable detection of somatic variants in patient brain tissue
Somatic variants are a major cause of human disease, including neurological disorders like focal epilepsies, but can be challenging to study due to their mosaicism in bulk tissue biopsies. Coupling single-cell genotype and transcriptomic data has potential to provide insight into the role somatic va...
Autores principales: | Townsend, Sydney E., Westfall, Jesse J., Navarro, Jason B., Koboldt, Daniel C., Mardis, Elaine R., Miller, Katherine E., Bedrosian, Tracy A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834227/ https://www.ncbi.nlm.nih.gov/pubmed/36631516 http://dx.doi.org/10.1038/s41598-023-27700-6 |
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