Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling

Cellular senescence and the senescence-associated secretory phenotype (SASP) are implicated in aging and age-related disease, and SASP-related inflammation is thought to contribute to tissue dysfunction in aging and diseased animals. However, whether and how SASP factors influence the regenerative c...

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Detalles Bibliográficos
Autores principales: Yun, Jina, Hansen, Simon, Morris, Otto, Madden, David T., Libeu, Clare Peters, Kumar, Arjun J., Wehrfritz, Cameron, Nile, Aaron H., Zhang, Yingnan, Zhou, Lijuan, Liang, Yuxin, Modrusan, Zora, Chen, Michelle B., Overall, Christopher C., Garfield, David, Campisi, Judith, Schilling, Birgit, Hannoush, Rami N., Jasper, Heinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834240/
https://www.ncbi.nlm.nih.gov/pubmed/36631445
http://dx.doi.org/10.1038/s41467-022-35487-9

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