Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring

Maternal nutrition plays a critical role in energy metabolism of offspring. We aim to elucidate the effect of long-term intermittent fasting (IF) before pregnancy on health outcomes of offspring. Here we show long-term IF before pregnancy disrupts intestinal homeostasis of offspring with subsequent...

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Autores principales: Liang, Yuan, Yin, Wenzhen, Luo, Chao, Sun, Lijun, Feng, Tiange, Zhang, Yunhua, Yin, Yue, Zhang, Weizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834385/
https://www.ncbi.nlm.nih.gov/pubmed/36631606
http://dx.doi.org/10.1038/s42003-022-04380-y
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author Liang, Yuan
Yin, Wenzhen
Luo, Chao
Sun, Lijun
Feng, Tiange
Zhang, Yunhua
Yin, Yue
Zhang, Weizhen
author_facet Liang, Yuan
Yin, Wenzhen
Luo, Chao
Sun, Lijun
Feng, Tiange
Zhang, Yunhua
Yin, Yue
Zhang, Weizhen
author_sort Liang, Yuan
collection PubMed
description Maternal nutrition plays a critical role in energy metabolism of offspring. We aim to elucidate the effect of long-term intermittent fasting (IF) before pregnancy on health outcomes of offspring. Here we show long-term IF before pregnancy disrupts intestinal homeostasis of offspring with subsequent disorder of glucose and lipid metabolism. This occurs through the reduction in beneficial microbiota such as Lactobacillus_intestinalis. Our observations further support the concept that intestinal microbiota in offspring is vulnerable to maternal nutrition, and its homeostasis is critical for the integrity of intestinal barrier and metabolic homeostasis.
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spelling pubmed-98343852023-01-13 Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring Liang, Yuan Yin, Wenzhen Luo, Chao Sun, Lijun Feng, Tiange Zhang, Yunhua Yin, Yue Zhang, Weizhen Commun Biol Article Maternal nutrition plays a critical role in energy metabolism of offspring. We aim to elucidate the effect of long-term intermittent fasting (IF) before pregnancy on health outcomes of offspring. Here we show long-term IF before pregnancy disrupts intestinal homeostasis of offspring with subsequent disorder of glucose and lipid metabolism. This occurs through the reduction in beneficial microbiota such as Lactobacillus_intestinalis. Our observations further support the concept that intestinal microbiota in offspring is vulnerable to maternal nutrition, and its homeostasis is critical for the integrity of intestinal barrier and metabolic homeostasis. Nature Publishing Group UK 2023-01-12 /pmc/articles/PMC9834385/ /pubmed/36631606 http://dx.doi.org/10.1038/s42003-022-04380-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Liang, Yuan
Yin, Wenzhen
Luo, Chao
Sun, Lijun
Feng, Tiange
Zhang, Yunhua
Yin, Yue
Zhang, Weizhen
Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
title Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
title_full Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
title_fullStr Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
title_full_unstemmed Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
title_short Maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
title_sort maternal intermittent fasting in mice disrupts the intestinal barrier leading to metabolic disorder in adult offspring
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834385/
https://www.ncbi.nlm.nih.gov/pubmed/36631606
http://dx.doi.org/10.1038/s42003-022-04380-y
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