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Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain

OBJECTIVE: In this study, we aimed to position the Hungarian Merino among other Merino-derived sheep breeds, explore the characteristics of our sampled animals' genetic similarity network within the breed, and highlight single nucleotide polymorphisms (SNPs) associated with daily weight-gain. M...

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Autores principales: Zsolnai, Attila, Egerszegi, István, Rózsa, László, Mezőszentgyörgyi, Dávid, Anton, István
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Animal Bioscience 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834658/
https://www.ncbi.nlm.nih.gov/pubmed/35760405
http://dx.doi.org/10.5713/ab.21.0459
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author Zsolnai, Attila
Egerszegi, István
Rózsa, László
Mezőszentgyörgyi, Dávid
Anton, István
author_facet Zsolnai, Attila
Egerszegi, István
Rózsa, László
Mezőszentgyörgyi, Dávid
Anton, István
author_sort Zsolnai, Attila
collection PubMed
description OBJECTIVE: In this study, we aimed to position the Hungarian Merino among other Merino-derived sheep breeds, explore the characteristics of our sampled animals' genetic similarity network within the breed, and highlight single nucleotide polymorphisms (SNPs) associated with daily weight-gain. METHODS: Hungarian Merino (n = 138) was genotyped on Ovine SNP50 Bead Chip (Illumina, San Diego, CA, USA) and positioned among 30 Merino and Merino-derived breeds (n = 555). Population characteristics were obtained via PLINK, SVS, Admixture, and Treemix software, within-breed network was analysed with python networkx 2.3 library. Daily weight gain of Hungarian Merino was standardised to 60 days and was collected from the database of the Association of Hungarian Sheep and Goat Breeders. For the identification of loci associated with daily weight gain, a multi-locus mixed-model was used. RESULTS: Supporting the breed's written history, the closest breeds to Hungarian Merino were Estremadura and Rambouillet (pairwise F(ST) values are 0.035 and 0.036, respectively). Among Hungarian Merino, a highly centralised connectedness has been revealed by network analysis of pairwise values of identity-by-state, where the animal in the central node had a betweenness centrality value equal to 0.936. Probing of daily weight gain against the SNP data of Hungarian Merinos revealed five associated loci. Two of them, OAR8_17854216.1 and s42441.1 on chromosome 8 and 9 (−log(10)P>22, false discovery rate<5.5e–20) and one locus on chromosome 20, s28948.1 (−log(10)P = 13.46, false discovery rate = 4.1e–11), were close to the markers reported in other breeds concerning daily weight gain, six-month weight, and post-weaning gain. CONCLUSION: The position of Hungarian Merino among other Merino breeds has been determined. We have described the similarity network of the individuals to be applied in breeding practices and highlighted several markers useful for elevating the daily weight gain of Hungarian Merino.
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spelling pubmed-98346582023-01-25 Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain Zsolnai, Attila Egerszegi, István Rózsa, László Mezőszentgyörgyi, Dávid Anton, István Anim Biosci Article OBJECTIVE: In this study, we aimed to position the Hungarian Merino among other Merino-derived sheep breeds, explore the characteristics of our sampled animals' genetic similarity network within the breed, and highlight single nucleotide polymorphisms (SNPs) associated with daily weight-gain. METHODS: Hungarian Merino (n = 138) was genotyped on Ovine SNP50 Bead Chip (Illumina, San Diego, CA, USA) and positioned among 30 Merino and Merino-derived breeds (n = 555). Population characteristics were obtained via PLINK, SVS, Admixture, and Treemix software, within-breed network was analysed with python networkx 2.3 library. Daily weight gain of Hungarian Merino was standardised to 60 days and was collected from the database of the Association of Hungarian Sheep and Goat Breeders. For the identification of loci associated with daily weight gain, a multi-locus mixed-model was used. RESULTS: Supporting the breed's written history, the closest breeds to Hungarian Merino were Estremadura and Rambouillet (pairwise F(ST) values are 0.035 and 0.036, respectively). Among Hungarian Merino, a highly centralised connectedness has been revealed by network analysis of pairwise values of identity-by-state, where the animal in the central node had a betweenness centrality value equal to 0.936. Probing of daily weight gain against the SNP data of Hungarian Merinos revealed five associated loci. Two of them, OAR8_17854216.1 and s42441.1 on chromosome 8 and 9 (−log(10)P>22, false discovery rate<5.5e–20) and one locus on chromosome 20, s28948.1 (−log(10)P = 13.46, false discovery rate = 4.1e–11), were close to the markers reported in other breeds concerning daily weight gain, six-month weight, and post-weaning gain. CONCLUSION: The position of Hungarian Merino among other Merino breeds has been determined. We have described the similarity network of the individuals to be applied in breeding practices and highlighted several markers useful for elevating the daily weight gain of Hungarian Merino. Animal Bioscience 2023-01 2022-06-24 /pmc/articles/PMC9834658/ /pubmed/35760405 http://dx.doi.org/10.5713/ab.21.0459 Text en Copyright © 2023 by Animal Bioscience https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Zsolnai, Attila
Egerszegi, István
Rózsa, László
Mezőszentgyörgyi, Dávid
Anton, István
Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain
title Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain
title_full Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain
title_fullStr Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain
title_full_unstemmed Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain
title_short Position of Hungarian Merino among other Merinos, within-breed genetic similarity network and markers associated with daily weight gain
title_sort position of hungarian merino among other merinos, within-breed genetic similarity network and markers associated with daily weight gain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834658/
https://www.ncbi.nlm.nih.gov/pubmed/35760405
http://dx.doi.org/10.5713/ab.21.0459
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