Functional substitutions of amino acids that differ between GDF11 and GDF8 impact skeletal development and skeletal muscle

Growth differentiation factor 11 (GDF11) and GDF8 (MSTN) are closely related TGF-β family proteins that interact with nearly identical signaling receptors and antagonists. However, GDF11 appears to activate SMAD2/3 more potently than GDF8 in vitro and in vivo. The ligands possess divergent structura...

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Detalles Bibliográficos
Autores principales: Lian, John, Walker, Ryan G, D’Amico, Andrea, Vujic, Ana, Mills, Melanie J, Messemer, Kathleen A, Mendello, Kourtney R, Goldstein, Jill M, Leacock, Krystynne A, Epp, Soraya, Stimpfl, Emma V, Thompson, Thomas B, Wagers, Amy J, Lee, Richard T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834663/
https://www.ncbi.nlm.nih.gov/pubmed/36631218
http://dx.doi.org/10.26508/lsa.202201662

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