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Medialisation laryngoplasty with bone wax in a sheep model
OBJECTIVE: To evaluate the safety and biocompatibility of bone wax as an implant material for medialisation laryngoplasty in a large animal model. METHODS: Three Dorper-cross ewes underwent type I thyroplasty of the right vocal fold with bone wax. The animals were monitored for four weeks for genera...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834703/ https://www.ncbi.nlm.nih.gov/pubmed/35510501 http://dx.doi.org/10.1017/S0022215122001086 |
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author | Nachalon, Y Cates, D J Nativ-Zeltzer, N Belafsky, P C |
author_facet | Nachalon, Y Cates, D J Nativ-Zeltzer, N Belafsky, P C |
author_sort | Nachalon, Y |
collection | PubMed |
description | OBJECTIVE: To evaluate the safety and biocompatibility of bone wax as an implant material for medialisation laryngoplasty in a large animal model. METHODS: Three Dorper-cross ewes underwent type I thyroplasty of the right vocal fold with bone wax. The animals were monitored for four weeks for general wellbeing. The animals were euthanised and the larynges harvested. Histological evaluation was performed to assess for adverse tissue reaction and biocompatibility. RESULTS: The mean (± standard deviation) amount of bone wax implanted was 0.49 g (± 0.12 g). No adverse events were reported. Ex vivo vibration was present on high-speed imaging for all medialised vocal folds. Histology demonstrated implanted paraffin embedded within the thyroarytenoid muscle with no evidence of resorption, a minimal inflammatory infiltrate, and a thin fibrotic capsule. CONCLUSION: The results of this investigation suggest that bone wax may be a safe and efficacious implant material for medialisation laryngoplasty. Further studies are necessary to assess its long-term safety and efficacy. |
format | Online Article Text |
id | pubmed-9834703 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-98347032023-01-18 Medialisation laryngoplasty with bone wax in a sheep model Nachalon, Y Cates, D J Nativ-Zeltzer, N Belafsky, P C J Laryngol Otol Main Article OBJECTIVE: To evaluate the safety and biocompatibility of bone wax as an implant material for medialisation laryngoplasty in a large animal model. METHODS: Three Dorper-cross ewes underwent type I thyroplasty of the right vocal fold with bone wax. The animals were monitored for four weeks for general wellbeing. The animals were euthanised and the larynges harvested. Histological evaluation was performed to assess for adverse tissue reaction and biocompatibility. RESULTS: The mean (± standard deviation) amount of bone wax implanted was 0.49 g (± 0.12 g). No adverse events were reported. Ex vivo vibration was present on high-speed imaging for all medialised vocal folds. Histology demonstrated implanted paraffin embedded within the thyroarytenoid muscle with no evidence of resorption, a minimal inflammatory infiltrate, and a thin fibrotic capsule. CONCLUSION: The results of this investigation suggest that bone wax may be a safe and efficacious implant material for medialisation laryngoplasty. Further studies are necessary to assess its long-term safety and efficacy. Cambridge University Press 2023-01 2022-05-05 /pmc/articles/PMC9834703/ /pubmed/35510501 http://dx.doi.org/10.1017/S0022215122001086 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Main Article Nachalon, Y Cates, D J Nativ-Zeltzer, N Belafsky, P C Medialisation laryngoplasty with bone wax in a sheep model |
title | Medialisation laryngoplasty with bone wax in a sheep model |
title_full | Medialisation laryngoplasty with bone wax in a sheep model |
title_fullStr | Medialisation laryngoplasty with bone wax in a sheep model |
title_full_unstemmed | Medialisation laryngoplasty with bone wax in a sheep model |
title_short | Medialisation laryngoplasty with bone wax in a sheep model |
title_sort | medialisation laryngoplasty with bone wax in a sheep model |
topic | Main Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834703/ https://www.ncbi.nlm.nih.gov/pubmed/35510501 http://dx.doi.org/10.1017/S0022215122001086 |
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