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Cerebrospinal fluid-derived circulating tumor DNA is more comprehensive than plasma in NSCLC patients with leptomeningeal metastases regardless of extracranial evolution

INTRODUCTION: Metastases to the central nervous system (CNS) are devastating neurological complications. Circulating cell-free tumor DNA (ctDNA) from cerebrospinal fluid (CSF) better represents genomic alterations in CNS tumors compared to plasma (PLA). However, the clinical value of cerebrospinal f...

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Detalles Bibliográficos
Autores principales:	Yang, Hainan, Wen, Lei, Zhao, Chao, Chen, Jianing, Zhou, Zhaoming, Zhou, Cheng, Cai, Linbo, Zhou, Caicun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834711/ https://www.ncbi.nlm.nih.gov/pubmed/36643302 http://dx.doi.org/10.1016/j.heliyon.2022.e12374

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