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Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures

OBJECTIVE: To evaluate the independent risk factors for elevated creatine kinase (hyperCKemia) after seizures. METHODS: Data included in this retrospective study were obtained from two hospitals from July 1, 2017, to March 31, 2022. Clinical and laboratory data were acquired from the emergency depar...

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Autores principales: Wang, Lei, Lu, Yanan, Yang, Yujing, Li, Hanli, Wang, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834749/
https://www.ncbi.nlm.nih.gov/pubmed/36643300
http://dx.doi.org/10.1016/j.heliyon.2022.e12509
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author Wang, Lei
Lu, Yanan
Yang, Yujing
Li, Hanli
Wang, Yu
author_facet Wang, Lei
Lu, Yanan
Yang, Yujing
Li, Hanli
Wang, Yu
author_sort Wang, Lei
collection PubMed
description OBJECTIVE: To evaluate the independent risk factors for elevated creatine kinase (hyperCKemia) after seizures. METHODS: Data included in this retrospective study were obtained from two hospitals from July 1, 2017, to March 31, 2022. Clinical and laboratory data were acquired from the emergency department or within 24 h after patient admission. Variables that exhibited statistical differences (P < 0.05) were selected for further analysis. Associations between body temperature (BT), leukocyte count (LEU), percentage of neutrophils (NEU), and C-reactive protein (CRP) and creatine kinase (CK) levels were assessed using binary logistic regression analysis. RESULTS: One hundred twenty-three patients who exhibited seizures were included in the study, and 39 (31.7%) patients exhibited hyperCKemia based on a CK level that was >1.5 times the upper limit of the normal range for CK. No statistical differences were observed among the patient characteristics, seizure-related parameters, or electrolyte levels. However, BT, LEU, NEU, and CRP were elevated in patients with hyperCKemia compared to patients with normal CK levels. Specifically, a BT ≥ 37.5 °C (fever) and LEU >9.5×10(9)/L (elevated LEU) exhibited positive correlations with hyperCKemia, and presented an adjusted OR of 8.87 (95% CI: 2.11–37.24, P = 0.003) and 3.01 (95% CI: 1.12–8.05, P = 0.029), respectively. CONCLUSION: In this study, hyperCKemia occurred in 31.7% of patients after seizures. Fever and elevated LEU were independent risk factors for seizure-related hyperCKemia. Earlier recognition of risks for seizure-related hyperCKemia would be beneficial in taking prophylactic measures.
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spelling pubmed-98347492023-01-13 Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures Wang, Lei Lu, Yanan Yang, Yujing Li, Hanli Wang, Yu Heliyon Research Article OBJECTIVE: To evaluate the independent risk factors for elevated creatine kinase (hyperCKemia) after seizures. METHODS: Data included in this retrospective study were obtained from two hospitals from July 1, 2017, to March 31, 2022. Clinical and laboratory data were acquired from the emergency department or within 24 h after patient admission. Variables that exhibited statistical differences (P < 0.05) were selected for further analysis. Associations between body temperature (BT), leukocyte count (LEU), percentage of neutrophils (NEU), and C-reactive protein (CRP) and creatine kinase (CK) levels were assessed using binary logistic regression analysis. RESULTS: One hundred twenty-three patients who exhibited seizures were included in the study, and 39 (31.7%) patients exhibited hyperCKemia based on a CK level that was >1.5 times the upper limit of the normal range for CK. No statistical differences were observed among the patient characteristics, seizure-related parameters, or electrolyte levels. However, BT, LEU, NEU, and CRP were elevated in patients with hyperCKemia compared to patients with normal CK levels. Specifically, a BT ≥ 37.5 °C (fever) and LEU >9.5×10(9)/L (elevated LEU) exhibited positive correlations with hyperCKemia, and presented an adjusted OR of 8.87 (95% CI: 2.11–37.24, P = 0.003) and 3.01 (95% CI: 1.12–8.05, P = 0.029), respectively. CONCLUSION: In this study, hyperCKemia occurred in 31.7% of patients after seizures. Fever and elevated LEU were independent risk factors for seizure-related hyperCKemia. Earlier recognition of risks for seizure-related hyperCKemia would be beneficial in taking prophylactic measures. Elsevier 2022-12-22 /pmc/articles/PMC9834749/ /pubmed/36643300 http://dx.doi.org/10.1016/j.heliyon.2022.e12509 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Wang, Lei
Lu, Yanan
Yang, Yujing
Li, Hanli
Wang, Yu
Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
title Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
title_full Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
title_fullStr Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
title_full_unstemmed Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
title_short Elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
title_sort elevated body temperature and leukocyte count are associated with elevated creatine kinase after seizures
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9834749/
https://www.ncbi.nlm.nih.gov/pubmed/36643300
http://dx.doi.org/10.1016/j.heliyon.2022.e12509
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