Cargando…
Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study
[Image: see text] In this paper, we develop a method for Friedel–Crafts acylation using metal triflate in deep eutectic solvents. Various metal triflates were tested and provided good to excellent yields of corresponding ketone products. The density functional theory calculation revealed the metal e...
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2022
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835085/ https://www.ncbi.nlm.nih.gov/pubmed/36643563 http://dx.doi.org/10.1021/acsomega.2c03944 |
| _version_ | 1784868599661330432 |
|---|---|
| author | Nguyen, Minh-Tam Thi Le, Nghia Nguyen, Hai Truong Luong, Tram Diem Vu Nguyen, Van Kieu Thuy Kawazoe, Yoshiyuki Tran, Phuong Hoang Pham-Tran, Nguyen-Nguyen |
| author_facet | Nguyen, Minh-Tam Thi Le, Nghia Nguyen, Hai Truong Luong, Tram Diem Vu Nguyen, Van Kieu Thuy Kawazoe, Yoshiyuki Tran, Phuong Hoang Pham-Tran, Nguyen-Nguyen |
| author_sort | Nguyen, Minh-Tam Thi |
| collection | PubMed |
| description | [Image: see text] In this paper, we develop a method for Friedel–Crafts acylation using metal triflate in deep eutectic solvents. Various metal triflates were tested and provided good to excellent yields of corresponding ketone products. The density functional theory calculation revealed the metal effects on the formation of active intermediate acylium triflate as well as the acidic condition. The metal triflate in the deep eutectic solvent can be recovered and reused with a little loss in the catalytic activity. |
| format | Online Article Text |
| id | pubmed-9835085 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-98350852023-01-13 Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study Nguyen, Minh-Tam Thi Le, Nghia Nguyen, Hai Truong Luong, Tram Diem Vu Nguyen, Van Kieu Thuy Kawazoe, Yoshiyuki Tran, Phuong Hoang Pham-Tran, Nguyen-Nguyen ACS Omega [Image: see text] In this paper, we develop a method for Friedel–Crafts acylation using metal triflate in deep eutectic solvents. Various metal triflates were tested and provided good to excellent yields of corresponding ketone products. The density functional theory calculation revealed the metal effects on the formation of active intermediate acylium triflate as well as the acidic condition. The metal triflate in the deep eutectic solvent can be recovered and reused with a little loss in the catalytic activity. American Chemical Society 2022-12-16 /pmc/articles/PMC9835085/ /pubmed/36643563 http://dx.doi.org/10.1021/acsomega.2c03944 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Nguyen, Minh-Tam Thi Le, Nghia Nguyen, Hai Truong Luong, Tram Diem Vu Nguyen, Van Kieu Thuy Kawazoe, Yoshiyuki Tran, Phuong Hoang Pham-Tran, Nguyen-Nguyen Mechanism of Friedel–Crafts Acylation Using Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational Study |
| title | Mechanism of Friedel–Crafts
Acylation Using
Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational
Study |
| title_full | Mechanism of Friedel–Crafts
Acylation Using
Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational
Study |
| title_fullStr | Mechanism of Friedel–Crafts
Acylation Using
Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational
Study |
| title_full_unstemmed | Mechanism of Friedel–Crafts
Acylation Using
Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational
Study |
| title_short | Mechanism of Friedel–Crafts
Acylation Using
Metal Triflate in Deep Eutectic Solvents: An Experimental and Computational
Study |
| title_sort | mechanism of friedel–crafts
acylation using
metal triflate in deep eutectic solvents: an experimental and computational
study |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835085/ https://www.ncbi.nlm.nih.gov/pubmed/36643563 http://dx.doi.org/10.1021/acsomega.2c03944 |
| work_keys_str_mv | AT nguyenminhtamthi mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT lenghia mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT nguyenhaitruong mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT luongtramdiemvu mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT nguyenvankieuthuy mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT kawazoeyoshiyuki mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT tranphuonghoang mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy AT phamtrannguyennguyen mechanismoffriedelcraftsacylationusingmetaltriflateindeepeutecticsolventsanexperimentalandcomputationalstudy |