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“THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury

To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the adequacy of cerebral perfusion. Multiple physiological parameters determine the oxygen deliver...

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Autores principales: Godoy, Daniel Agustin, Murillo-Cabezas, Francisco, Suarez, Jose Ignacio, Badenes, Rafael, Pelosi, Paolo, Robba, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835224/
https://www.ncbi.nlm.nih.gov/pubmed/36635711
http://dx.doi.org/10.1186/s13054-022-04242-3
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author Godoy, Daniel Agustin
Murillo-Cabezas, Francisco
Suarez, Jose Ignacio
Badenes, Rafael
Pelosi, Paolo
Robba, Chiara
author_facet Godoy, Daniel Agustin
Murillo-Cabezas, Francisco
Suarez, Jose Ignacio
Badenes, Rafael
Pelosi, Paolo
Robba, Chiara
author_sort Godoy, Daniel Agustin
collection PubMed
description To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the adequacy of cerebral perfusion. Multiple physiological parameters determine the oxygen delivered to the brain, including blood pressure, hemoglobin level, systemic oxygenation, microcirculation and many factors are involved in the delivery of oxygen to its final recipient, through the respiratory chain. Brain tissue hypoxia occurs when the supply of oxygen is not adequate or when for some reasons it cannot be used at the cellular level. The causes of hypoxia are variable and can be analyzed pathophysiologically following “the oxygen route.” The current trend is precision medicine, individualized and therapeutically directed to the pathophysiology of specific brain damage; however, this requires the availability of multimodal monitoring. For this purpose, we developed the acronym “THE MANTLE,” a bundle of therapeutical interventions, which covers and protects the brain, optimizing the components of the oxygen transport system from ambient air to the mitochondria.
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spelling pubmed-98352242023-01-13 “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury Godoy, Daniel Agustin Murillo-Cabezas, Francisco Suarez, Jose Ignacio Badenes, Rafael Pelosi, Paolo Robba, Chiara Crit Care Perspective To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the adequacy of cerebral perfusion. Multiple physiological parameters determine the oxygen delivered to the brain, including blood pressure, hemoglobin level, systemic oxygenation, microcirculation and many factors are involved in the delivery of oxygen to its final recipient, through the respiratory chain. Brain tissue hypoxia occurs when the supply of oxygen is not adequate or when for some reasons it cannot be used at the cellular level. The causes of hypoxia are variable and can be analyzed pathophysiologically following “the oxygen route.” The current trend is precision medicine, individualized and therapeutically directed to the pathophysiology of specific brain damage; however, this requires the availability of multimodal monitoring. For this purpose, we developed the acronym “THE MANTLE,” a bundle of therapeutical interventions, which covers and protects the brain, optimizing the components of the oxygen transport system from ambient air to the mitochondria. BioMed Central 2023-01-12 /pmc/articles/PMC9835224/ /pubmed/36635711 http://dx.doi.org/10.1186/s13054-022-04242-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Perspective
Godoy, Daniel Agustin
Murillo-Cabezas, Francisco
Suarez, Jose Ignacio
Badenes, Rafael
Pelosi, Paolo
Robba, Chiara
“THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
title “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
title_full “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
title_fullStr “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
title_full_unstemmed “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
title_short “THE MANTLE” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
title_sort “the mantle” bundle for minimizing cerebral hypoxia in severe traumatic brain injury
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835224/
https://www.ncbi.nlm.nih.gov/pubmed/36635711
http://dx.doi.org/10.1186/s13054-022-04242-3
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