Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging

The most common malignant brain tumour in children, medulloblastoma (MB), is subdivided into four clinically relevant molecular subgroups, although targeted therapy options informed by understanding of different cellular features are lacking. Here, by comparing the most aggressive subgroup (Group 3)...

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Detalles Bibliográficos
Autores principales: Linke, Franziska, Johnson, James E. C., Kern, Stefanie, Bennett, Christopher D., Lourdusamy, Anbarasu, Lea, Daniel, Clifford, Steven C., Merry, Catherine L. R., Stolnik, Snow, Alexander, Morgan R., Peet, Andrew C., Scurr, David J., Griffiths, Rian L., Grabowska, Anna M., Kerr, Ian D., Coyle, Beth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835248/
https://www.ncbi.nlm.nih.gov/pubmed/36631900
http://dx.doi.org/10.1186/s40478-022-01496-4

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