Systemic interindividual epigenetic variation in humans is associated with transposable elements and under strong genetic control

BACKGROUND: Genetic variants can modulate phenotypic outcomes via epigenetic intermediates, for example at methylation quantitative trait loci (mQTL). We present the first large-scale assessment of mQTL at human genomic regions selected for interindividual variation in CpG methylation, which we call...

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Detalles Bibliográficos
Autores principales: Gunasekara, Chathura J., MacKay, Harry, Scott, C. Anthony, Li, Shaobo, Laritsky, Eleonora, Baker, Maria S., Grimm, Sandra L., Jun, Goo, Li, Yumei, Chen, Rui, Wiemels, Joseph L., Coarfa, Cristian, Waterland, Robert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835319/
https://www.ncbi.nlm.nih.gov/pubmed/36631879
http://dx.doi.org/10.1186/s13059-022-02827-3

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