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Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications

[Image: see text] Archaeosomes are a new generation of stable liposomes composed of natural ether lipids extracted from archaea, or synthetic archaeal lipids. Archaea constitute a domain of single-celled microorganisms that are structurally similar to but evolutionarily distinct from bacteria. They...

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Autores principales: Santhosh, Poornima Budime, Genova, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835528/
https://www.ncbi.nlm.nih.gov/pubmed/36643444
http://dx.doi.org/10.1021/acsomega.2c06034
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author Santhosh, Poornima Budime
Genova, Julia
author_facet Santhosh, Poornima Budime
Genova, Julia
author_sort Santhosh, Poornima Budime
collection PubMed
description [Image: see text] Archaeosomes are a new generation of stable liposomes composed of natural ether lipids extracted from archaea, or synthetic archaeal lipids. Archaea constitute a domain of single-celled microorganisms that are structurally similar to but evolutionarily distinct from bacteria. They synthesize unique membrane lipids with isoprenoid hydrocarbon side chains attached via an ether linkage to the glycerol-phosphate backbone. Compared to the ester linkages found in the lipids of Eukarya and bacteria, the ether linkages in archaeal lipids are more stable in various environmental conditions such as high/low temperatures, acidic or alkaline pH, bile salts, and enzymatic hydrolysis. This feature has intrigued scientists to use archaeal lipids to prepare archaeosomes with superior physicochemical stability and utilize them as effective carriers to deliver various cargos of biomedical importance such as drugs, proteins, peptides, genes, and antioxidants to the target site. Archaeosomes carrying antigens and/or adjuvants are also proven to be better candidates for stimulating antigen-specific, humoral, and cell-mediated immune responses, which broadens their scope in vaccine delivery. These properties associated with excellent biocompatibility and a safety profile provide numerous advantages to the archaeosomes to function as a versatile delivery system. This mini-review will provide an overview of the unique features of archaeal lipids, preparation and characterization of archaeosomes, and emphasize the prospects related to drug delivery and other biomedical applications.
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spelling pubmed-98355282023-01-13 Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications Santhosh, Poornima Budime Genova, Julia ACS Omega [Image: see text] Archaeosomes are a new generation of stable liposomes composed of natural ether lipids extracted from archaea, or synthetic archaeal lipids. Archaea constitute a domain of single-celled microorganisms that are structurally similar to but evolutionarily distinct from bacteria. They synthesize unique membrane lipids with isoprenoid hydrocarbon side chains attached via an ether linkage to the glycerol-phosphate backbone. Compared to the ester linkages found in the lipids of Eukarya and bacteria, the ether linkages in archaeal lipids are more stable in various environmental conditions such as high/low temperatures, acidic or alkaline pH, bile salts, and enzymatic hydrolysis. This feature has intrigued scientists to use archaeal lipids to prepare archaeosomes with superior physicochemical stability and utilize them as effective carriers to deliver various cargos of biomedical importance such as drugs, proteins, peptides, genes, and antioxidants to the target site. Archaeosomes carrying antigens and/or adjuvants are also proven to be better candidates for stimulating antigen-specific, humoral, and cell-mediated immune responses, which broadens their scope in vaccine delivery. These properties associated with excellent biocompatibility and a safety profile provide numerous advantages to the archaeosomes to function as a versatile delivery system. This mini-review will provide an overview of the unique features of archaeal lipids, preparation and characterization of archaeosomes, and emphasize the prospects related to drug delivery and other biomedical applications. American Chemical Society 2022-12-28 /pmc/articles/PMC9835528/ /pubmed/36643444 http://dx.doi.org/10.1021/acsomega.2c06034 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Santhosh, Poornima Budime
Genova, Julia
Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications
title Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications
title_full Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications
title_fullStr Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications
title_full_unstemmed Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications
title_short Archaeosomes: New Generation of Liposomes Based on Archaeal Lipids for Drug Delivery and Biomedical Applications
title_sort archaeosomes: new generation of liposomes based on archaeal lipids for drug delivery and biomedical applications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835528/
https://www.ncbi.nlm.nih.gov/pubmed/36643444
http://dx.doi.org/10.1021/acsomega.2c06034
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