Cargando…

Exosomal miR‐532‐5p induced by long‐term exercise rescues blood–brain barrier function in 5XFAD mice via downregulation of EPHA4

The breakdown of the blood–brain barrier, which develops early in Alzheimer's disease (AD), contributes to cognitive impairment. Exercise not only reduces the risk factors for AD but also confers direct protection against cognitive decline. However, the exact molecular mechanisms remain elusive...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Xiaoyan, Fa, Wenxin, Wang, Nan, Peng, Yuanming, Liu, Cuicui, Zhu, Min, Tian, Na, Wang, Yongxiang, Han, Xiaolei, Qiu, Chengxuan, Hou, Tingting, Du, Yifeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835579/ https://www.ncbi.nlm.nih.gov/pubmed/36494892 http://dx.doi.org/10.1111/acel.13748

Ejemplares similares

KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a
por: Song, Lin, et al.
Publicado: (2019)

Downregulation of EphA5 by promoter methylation in human prostate cancer
por: Li, Shibao, et al.
Publicado: (2015)

KIBRA regulates amyloid β metabolism by controlling extracellular vesicles secretion
por: Han, Xiaolei, et al.
Publicado: (2022)

Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
por: Rodríguez-Urgellés, Ened, et al.
Publicado: (2022)

Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease
por: Wang, Lu, et al.
Publicado: (2016)

Microarray microRNA profiling of urinary exosomes in a 5XFAD mouse model of Alzheimer’s disease
por: Song, Zhiqi, et al.
Publicado: (2021)

Triglyceride–glucose index, Alzheimer's disease plasma biomarkers, and dementia in older adults: The MIND‐China study
por: Tian, Na, et al.
Publicado: (2023)

Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer’s disease
por: Kaminari, Archontia, et al.
Publicado: (2017)

EphA5 and EphA6: regulation of neuronal and spine morphology
por: Das, Gitanjali, et al.
Publicado: (2016)

Genetic Effects of NDUFAF6 rs6982393 and APOE on Alzheimer’s Disease in Chinese Rural Elderly: A Cross-Sectional Population-Based Study
por: Cheng, Yingzhe, et al.
Publicado: (2022)

Exosomal MicroRNA-10a Is Associated with Liver Regeneration in Rats through Downregulation of EphA4
por: Luo, Lin, et al.
Publicado: (2018)

Alteration of Neural Network and Hippocampal Slice Activation through Exosomes Derived from 5XFAD Nasal Lavage Fluid
por: Kim, Sangseong, et al.
Publicado: (2023)

Adiponectin improves long-term potentiation in the 5XFAD mouse brain
por: Wang, Ming, et al.
Publicado: (2019)

Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study
por: Wang, Yongxiang, et al.
Publicado: (2023)

Assessment of neurodegeneration and neuronal loss in aged 5XFAD mice
por: Zhang, Liansheng, et al.
Publicado: (2021)

Inflammation-dependent downregulation of miR-532-3p mediates apoptotic signaling in human sarcopenia through targeting BAK1
por: Chen, Fa-Xiu, et al.
Publicado: (2020)

Transient Cerebral Ischemia Promotes Brain Mitochondrial Dysfunction and Exacerbates Cognitive Impairments in Young 5xFAD Mice
por: Lu, Lin, et al.
Publicado: (2015)

NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice
por: Companys-Alemany, Júlia, et al.
Publicado: (2022)

Downregulation of EphA2 stability by RNF5 limits its tumor-suppressive function in HER2-negative breast cancers
por: Li, Xiaojuan, et al.
Publicado: (2023)

Comprehensive Proteomic Profiling of Urinary Exosomes and Identification of Potential Non-invasive Early Biomarkers of Alzheimer’s Disease in 5XFAD Mouse Model
por: Song, Zhiqi, et al.
Publicado: (2020)

Early Detection of Cerebral Glucose Uptake Changes in the 5XFAD Mouse
por: I.R, Macdonald, et al.
Publicado: (2014)

Aromatase Expression in the Hippocampus of AD Patients and 5xFAD Mice
por: Prange-Kiel, Janine, et al.
Publicado: (2016)

ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease
por: Sadleir, Katherine R., et al.
Publicado: (2018)

5XFAD Mice Show Early Onset Gap Detection Deficits
por: Kaylegian, Katherine, et al.
Publicado: (2019)

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
por: Sadleir, Katherine R., et al.
Publicado: (2021)

Ephrin Receptors (Eph): EphA1, EphA5, and EphA7 Expression in Uveal Melanoma—Associations with Clinical Parameters and Patient Survival
por: Gajdzis, Malgorzata, et al.
Publicado: (2020)

Associations of Cardiac Ventricular Repolarization with Serum Adhesion Molecules and Cognitive Function in Older Adults: The MIND-China Study
por: Wang, Chaoqun, et al.
Publicado: (2023)

Ventricular Electrocardiographic Signatures Associated with Dementia and Plasma Alzheimer’s Disease Biomarkers in Older Adults: A Population-Based Study
por: Mao, Ming, et al.
Publicado: (2023)

Phospho-eIF2α Level Is Important for Determining Abilities of BACE1 Reduction to Rescue Cholinergic Neurodegeneration and Memory Defects in 5XFAD Mice
por: Devi, Latha, et al.
Publicado: (2010)

Plasma Amyloid-β, Total Tau, and Neurofilament Light Chain Across the Alzheimer’s Disease Clinical Spectrum: A Population-Based Study
por: Dong, Yi, et al.
Publicado: (2023)

Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1-EPHA2 forward signaling
por: Han, Baoai, et al.
Publicado: (2022)

Lifespan Intellectual Factors, Genetic Susceptibility, and Cognitive Phenotypes in Aging: Implications for Interventions
por: Wang, Yongxiang, et al.
Publicado: (2019)

Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice
por: Duncan, Marilyn J., et al.
Publicado: (2019)

Phloroglucinol Attenuates the Cognitive Deficits of the 5XFAD Mouse Model of Alzheimer’s Disease
por: Yang, Eun-Jeong, et al.
Publicado: (2015)

Fructus mume extracts alleviate cognitive impairments in 5XFAD transgenic mice
por: Park, Jung-Cheol, et al.
Publicado: (2016)

Axonal and myelinic pathology in 5xFAD Alzheimer’s mouse spinal cord
por: Chu, Tak-Ho, et al.
Publicado: (2017)

4-Hydroxynonenal Immunoreactivity Is Increased in the Frontal Cortex of 5XFAD Transgenic Mice
por: Shin, Sang-Wook, et al.
Publicado: (2020)

The VEGF inhibitor vatalanib regulates AD pathology in 5xFAD mice
por: Jeon, Seong Gak, et al.
Publicado: (2020)

Intranasal Dantrolene as a Disease-Modifying Drug in Alzheimer 5XFAD Mice
por: Shi, Yun, et al.
Publicado: (2020)

Centella Asiatica Improves Memory and Promotes Antioxidative Signaling in 5XFAD Mice
por: Matthews, Donald G, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_8f18lfoeksconaiguev0m6vc5e