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Depletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts

Growth differentiation factor 15 (GDF15) is a stress‐responsive cytokine also known as a mitokine; however, its role in mitochondrial homeostasis and cellular senescence remained elusive. We show here that knocking down GDF15 expression in human dermal fibroblasts induced mitochondrial dysfunction a...

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Detalles Bibliográficos
Autores principales: Wedel, Sophia, Martic, Ines, Guerrero Navarro, Lena, Ploner, Christian, Pierer, Gerhard, Jansen‐Dürr, Pidder, Cavinato, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835581/
https://www.ncbi.nlm.nih.gov/pubmed/36547021
http://dx.doi.org/10.1111/acel.13752