A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype

We present a potential mechanism for emergence of catalytic activity that is essential for survival, from a non-catalytic protein fold. The type B dihydrofolate reductase (DfrB) family of enzymes were first identified in pathogenic bacteria because their dihydrofolate reductase activity is sufficien...

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Detalles Bibliográficos
Autores principales: Lemay-St-Denis, Claudèle, Alejaldre, Lorea, Jemouai, Zakaria, Lafontaine, Kiana, St-Aubin, Maxime, Hitache, Katia, Valikhani, Donya, Weerasinghe, Nuwani W., Létourneau, Myriam, Thibodeaux, Christopher J., Doucet, Nicolas, Baron, Christian, Copp, Janine N., Pelletier, Joelle N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835603/
https://www.ncbi.nlm.nih.gov/pubmed/36633286
http://dx.doi.org/10.1098/rstb.2022.0040

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