Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#

[Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzin...

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Autores principales: Xu, Yibo, Wang, Dongyang, Lv, Qianqian, Fu, Peng, Wang, Ying, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/
https://www.ncbi.nlm.nih.gov/pubmed/36643451
http://dx.doi.org/10.1021/acsomega.2c07038
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author Xu, Yibo
Wang, Dongyang
Lv, Qianqian
Fu, Peng
Wang, Ying
Zhu, Weiming
author_facet Xu, Yibo
Wang, Dongyang
Lv, Qianqian
Fu, Peng
Wang, Ying
Zhu, Weiming
author_sort Xu, Yibo
collection PubMed
description [Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC(50) values ranging from 8.83 to 10.52 μM.
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spelling pubmed-98356372023-01-13 Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166# Xu, Yibo Wang, Dongyang Lv, Qianqian Fu, Peng Wang, Ying Zhu, Weiming ACS Omega [Image: see text] Three new dimeric polyketides, i.e., phaeochromycins I–K (1–3, respectively) and a known polyketide phaeochromycin F (4), were isolated from the culture broth of a saline Qinghai–Tibet Plateau permafrost soil-derived Streptomyces sp. 166#. The structures were determined by analyzing one-dimensional and two-dimensional NMR as well as HRESIMS data. Compounds 2 and 3 exhibited a selective antiproliferative activity against H1299 and HUCCT1 cell lines, exhibiting IC(50) values ranging from 8.83 to 10.52 μM. American Chemical Society 2022-12-20 /pmc/articles/PMC9835637/ /pubmed/36643451 http://dx.doi.org/10.1021/acsomega.2c07038 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Xu, Yibo
Wang, Dongyang
Lv, Qianqian
Fu, Peng
Wang, Ying
Zhu, Weiming
Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_full Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_fullStr Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_full_unstemmed Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_short Phaeochromycins I–K, Three Methylene-Bridged Dimeric Polyketides from Streptomyces sp. 166#
title_sort phaeochromycins i–k, three methylene-bridged dimeric polyketides from streptomyces sp. 166#
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835637/
https://www.ncbi.nlm.nih.gov/pubmed/36643451
http://dx.doi.org/10.1021/acsomega.2c07038
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