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Discovery of Pongol, the Furanoflavonoid, as an Inhibitor of CDK7/Cyclin H/MAT1 and Its Preliminary Structure–Activity Relationship

[Image: see text] Natural products have been a great source of leads for cancer drug discovery. The cyclin-dependent kinases (CDKs) play a vital role in the initiation and progression of cancer. The CDK-activating kinase, CDK7/cyclin H/MAT1, has recently gained tremendous attention in targeted cance...

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Detalles Bibliográficos
Autores principales:	Bhurta, Deendyal, Bharate, Sandip B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835647/ https://www.ncbi.nlm.nih.gov/pubmed/36643464 http://dx.doi.org/10.1021/acsomega.2c06733

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