Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water

[Image: see text] Described herein is a concise and practical direct amidation at the C-3 position of quinoxalin-2(1H)-ones through an acid-promoted carbamoylation with isocyanide in water. In this conversion, environmentally friendly water and commercial inexpensive isocyanide were used as a solven...

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Autores principales: Li, Yong, Song, Gui-Ting, Tang, Dian-Yong, Xu, Zhi-Gang, Chen, Zhong-Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835787/
https://www.ncbi.nlm.nih.gov/pubmed/36643431
http://dx.doi.org/10.1021/acsomega.2c06946
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author Li, Yong
Song, Gui-Ting
Tang, Dian-Yong
Xu, Zhi-Gang
Chen, Zhong-Zhu
author_facet Li, Yong
Song, Gui-Ting
Tang, Dian-Yong
Xu, Zhi-Gang
Chen, Zhong-Zhu
author_sort Li, Yong
collection PubMed
description [Image: see text] Described herein is a concise and practical direct amidation at the C-3 position of quinoxalin-2(1H)-ones through an acid-promoted carbamoylation with isocyanide in water. In this conversion, environmentally friendly water and commercial inexpensive isocyanide were used as a solvent and carbamoylation reagent, respectively. This study not only provides a green and efficient strategy for the construction of 3-carbamoylquinoxalin-2(1H)-one derivatives that can be applied to the synthesis of druglike structures but also expands the application of isocyanide in organic chemistry.
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spelling pubmed-98357872023-01-13 Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water Li, Yong Song, Gui-Ting Tang, Dian-Yong Xu, Zhi-Gang Chen, Zhong-Zhu ACS Omega [Image: see text] Described herein is a concise and practical direct amidation at the C-3 position of quinoxalin-2(1H)-ones through an acid-promoted carbamoylation with isocyanide in water. In this conversion, environmentally friendly water and commercial inexpensive isocyanide were used as a solvent and carbamoylation reagent, respectively. This study not only provides a green and efficient strategy for the construction of 3-carbamoylquinoxalin-2(1H)-one derivatives that can be applied to the synthesis of druglike structures but also expands the application of isocyanide in organic chemistry. American Chemical Society 2022-12-16 /pmc/articles/PMC9835787/ /pubmed/36643431 http://dx.doi.org/10.1021/acsomega.2c06946 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Li, Yong
Song, Gui-Ting
Tang, Dian-Yong
Xu, Zhi-Gang
Chen, Zhong-Zhu
Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water
title Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water
title_full Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water
title_fullStr Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water
title_full_unstemmed Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water
title_short Acid-Promoted Direct C–H Carbamoylation at the C-3 Position of Quinoxalin-2(1H)-ones with Isocyanide in Water
title_sort acid-promoted direct c–h carbamoylation at the c-3 position of quinoxalin-2(1h)-ones with isocyanide in water
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835787/
https://www.ncbi.nlm.nih.gov/pubmed/36643431
http://dx.doi.org/10.1021/acsomega.2c06946
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