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Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study
BACKGROUND: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages. METHODS: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835990/ https://www.ncbi.nlm.nih.gov/pubmed/36655222 http://dx.doi.org/10.1183/23120541.00074-2022 |
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author | Hedman, Linnéa Almqvist, Linnéa Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva |
author_facet | Hedman, Linnéa Almqvist, Linnéa Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva |
author_sort | Hedman, Linnéa |
collection | PubMed |
description | BACKGROUND: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages. METHODS: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invited) was recruited at age 8 years to a prospective study about asthma. The cohort was followed annually from age 8 to 19 years and at 28 years by questionnaire surveys (67% of the original cohort participated). Asthma was categorised as never-asthma, onset age ≤8 years, onset age 9–13 years, onset age 14–19 years or onset age >19 years. RESULTS: Of the 3430 individuals in the cohort, 690 (20.1%) reported asthma in any survey. The average incidence rate was 10.0/1000 per year at ≤8 years, 11.9/1000 per year at 9–13 years, 13.3/1000 per year at 14–19 years and 6.1/1000 per year at >19 years. The incidence was higher among boys until age 10 years, but from age 15 years, it became higher among girls. Family history of asthma, allergic sensitisation and breastfeeding <3 months were associated with asthma onset throughout the study. Low birthweight, maternal smoking during pregnancy, severe respiratory infection, rhinoconjunctivitis and eczema were associated with asthma onset ≤8 and 9–13 years. CONCLUSIONS: The incidence of asthma was high during childhood and the teenage period, and decreased substantially during young adulthood. Early-life factors were associated with asthma onset throughout childhood but had also a lasting effect on asthma incidence until adulthood. |
format | Online Article Text |
id | pubmed-9835990 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-98359902023-01-17 Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study Hedman, Linnéa Almqvist, Linnéa Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva ERJ Open Res Original Research Articles BACKGROUND: The objective was to estimate the incidence rate of asthma from age 8 to 28 years and evaluate early-life risk factors for asthma onset at different ages. METHODS: In 1996, within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of 3430 schoolchildren (97% of invited) was recruited at age 8 years to a prospective study about asthma. The cohort was followed annually from age 8 to 19 years and at 28 years by questionnaire surveys (67% of the original cohort participated). Asthma was categorised as never-asthma, onset age ≤8 years, onset age 9–13 years, onset age 14–19 years or onset age >19 years. RESULTS: Of the 3430 individuals in the cohort, 690 (20.1%) reported asthma in any survey. The average incidence rate was 10.0/1000 per year at ≤8 years, 11.9/1000 per year at 9–13 years, 13.3/1000 per year at 14–19 years and 6.1/1000 per year at >19 years. The incidence was higher among boys until age 10 years, but from age 15 years, it became higher among girls. Family history of asthma, allergic sensitisation and breastfeeding <3 months were associated with asthma onset throughout the study. Low birthweight, maternal smoking during pregnancy, severe respiratory infection, rhinoconjunctivitis and eczema were associated with asthma onset ≤8 and 9–13 years. CONCLUSIONS: The incidence of asthma was high during childhood and the teenage period, and decreased substantially during young adulthood. Early-life factors were associated with asthma onset throughout childhood but had also a lasting effect on asthma incidence until adulthood. European Respiratory Society 2022-12-12 /pmc/articles/PMC9835990/ /pubmed/36655222 http://dx.doi.org/10.1183/23120541.00074-2022 Text en Copyright ©The authors 2022 https://creativecommons.org/licenses/by/4.0/This version is distributed under the terms of the Creative Commons Attribution Licence 4.0. |
spellingShingle | Original Research Articles Hedman, Linnéa Almqvist, Linnéa Bjerg, Anders Andersson, Martin Backman, Helena Perzanowski, Matthew S. Rönmark, Eva Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
title | Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
title_full | Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
title_fullStr | Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
title_full_unstemmed | Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
title_short | Early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
title_sort | early-life risk factors for development of asthma from 8 to 28 years of age: a prospective cohort study |
topic | Original Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835990/ https://www.ncbi.nlm.nih.gov/pubmed/36655222 http://dx.doi.org/10.1183/23120541.00074-2022 |
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