Administration of aerosolized SARS-CoV-2 to K18-hACE2 mice uncouples respiratory infection from fatal neuroinvasion

The development of a tractable small animal model faithfully reproducing human COVID-19 pathogenesis would arguably meet a pressing need in biomedical research. Thus far, most investigators have used transgenic mice expressing the human ACE2 in epithelial cells (K18-hACE2 transgenic mice) that are i...

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Detalles Bibliográficos
Autores principales: Fumagalli, Valeria, Ravà, Micol, Marotta, Davide, Di Lucia, Pietro, Laura, Chiara, Sala, Eleonora, Grillo, Marta, Bono, Elisa, Giustini, Leonardo, Perucchini, Chiara, Mainetti, Marta, Sessa, Alessandro, Garcia-Manteiga, José M., Donnici, Lorena, Manganaro, Lara, Delbue, Serena, Broccoli, Vania, De Francesco, Raffaele, D’Adamo, Patrizia, Kuka, Mirela, Guidotti, Luca G., Iannacone, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9835999/
https://www.ncbi.nlm.nih.gov/pubmed/34812647
http://dx.doi.org/10.1126/sciimmunol.abl9929

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