Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer’s Disease Brains and Mouse Neurodegeneration Models

Wnt signaling is crucial for synapse and cognitive function. Indeed, deficient Wnt signaling is causally related to increased expression of DKK1, an endogenous negative Wnt regulator, and synapse loss, both of which likely contribute to cognitive decline in Alzheimer’s disease (AD). Increasingly, AD...

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Detalles Bibliográficos
Autores principales: Aghaizu, Nozie D., Jolly, Sarah, Samra, Satinder K., Kalmar, Bernadett, Craessaerts, Katleen, Greensmith, Linda, Salinas, Patricia C., De Strooper, Bart, Whiting, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2023
Materias:
Research Article: New Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836029/
https://www.ncbi.nlm.nih.gov/pubmed/36599670
http://dx.doi.org/10.1523/ENEURO.0306-22.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836029/
https://www.ncbi.nlm.nih.gov/pubmed/36599670
http://dx.doi.org/10.1523/ENEURO.0306-22.2022

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