PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis

Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the...

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Autores principales: Quintanilla, Samantha Y., Arejan, Neda Habibi, Patel, Parthvi B., Boutte, Cara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836265/
https://www.ncbi.nlm.nih.gov/pubmed/36634117
http://dx.doi.org/10.1371/journal.pone.0280336
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author Quintanilla, Samantha Y.
Arejan, Neda Habibi
Patel, Parthvi B.
Boutte, Cara C.
author_facet Quintanilla, Samantha Y.
Arejan, Neda Habibi
Patel, Parthvi B.
Boutte, Cara C.
author_sort Quintanilla, Samantha Y.
collection PubMed
description Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci.
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spelling pubmed-98362652023-01-13 PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis Quintanilla, Samantha Y. Arejan, Neda Habibi Patel, Parthvi B. Boutte, Cara C. PLoS One Research Article Mycobacteria expand their cell walls at the cell poles in a manner that is not well described at the molecular level. In this study, we identify a new polar factor, PlrA, that is involved in restricting peptidoglycan metabolism to the cell poles in Mycobacterium smegmatis. We establish that only the N-terminal membrane domain of PlrA is essential. We show that depletion of plrA pheno-copies depletion of polar growth factor Wag31, and that PlrA is involved in regulating the Wag31 polar foci. Public Library of Science 2023-01-12 /pmc/articles/PMC9836265/ /pubmed/36634117 http://dx.doi.org/10.1371/journal.pone.0280336 Text en © 2023 Quintanilla et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Quintanilla, Samantha Y.
Arejan, Neda Habibi
Patel, Parthvi B.
Boutte, Cara C.
PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
title PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
title_full PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
title_fullStr PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
title_full_unstemmed PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
title_short PlrA (MSMEG_5223) is an essential polar growth regulator in Mycobacterium smegmatis
title_sort plra (msmeg_5223) is an essential polar growth regulator in mycobacterium smegmatis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836265/
https://www.ncbi.nlm.nih.gov/pubmed/36634117
http://dx.doi.org/10.1371/journal.pone.0280336
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