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Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing

Endoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker for UC. This study aimed to evaluate the clinical utility of the NL...

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Autores principales: Kurimoto, Noriyuki, Nishida, Yu, Hosomi, Shuhei, Itani, Shigehiro, Kobayashi, Yumie, Nakata, Rieko, Ominami, Masaki, Nadatani, Yuji, Fukunaga, Shusei, Otani, Koji, Tanaka, Fumio, Nagami, Yasuaki, Taira, Koichi, Kamata, Noriko, Fujiwara, Yasuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836288/
https://www.ncbi.nlm.nih.gov/pubmed/36634124
http://dx.doi.org/10.1371/journal.pone.0280252
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author Kurimoto, Noriyuki
Nishida, Yu
Hosomi, Shuhei
Itani, Shigehiro
Kobayashi, Yumie
Nakata, Rieko
Ominami, Masaki
Nadatani, Yuji
Fukunaga, Shusei
Otani, Koji
Tanaka, Fumio
Nagami, Yasuaki
Taira, Koichi
Kamata, Noriko
Fujiwara, Yasuhiro
author_facet Kurimoto, Noriyuki
Nishida, Yu
Hosomi, Shuhei
Itani, Shigehiro
Kobayashi, Yumie
Nakata, Rieko
Ominami, Masaki
Nadatani, Yuji
Fukunaga, Shusei
Otani, Koji
Tanaka, Fumio
Nagami, Yasuaki
Taira, Koichi
Kamata, Noriko
Fujiwara, Yasuhiro
author_sort Kurimoto, Noriyuki
collection PubMed
description Endoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker for UC. This study aimed to evaluate the clinical utility of the NLR for predicting clinical relapse in UC patients with MH. We retrospectively enrolled patients with UC who underwent colonoscopy at the Osaka City University Hospital between January 2010 and December 2010, whose Mayo Endoscopic Subscore was 0 or 1. The correlation between the incidence of relapse and demographic factors, including the NLR, was analyzed. We included 129 patients in the present study. The median NLR at the time of endoscopy was 1.98, and differences in the high NLR group and the low NLR group were compared. During a median follow-up period of 46.4 months, 58 patients (45.0%) experienced relapse. The cumulative relapse-free rate was significantly higher in the low NLR group than in the high NLR group (P = 0.03, log-rank test). Multivariate analysis identified high NLR as an independent prognostic factor for clinical relapse (hazard ratio, 1.74; 95% confidence interval, 1.02–2.98; P = 0.04). NLR is a novel and useful predictor of clinical relapse in UC patients with MH, and it can potentially be a strong indicator to determine the appropriate treatment strategy and decision-making in clinical practice.
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spelling pubmed-98362882023-01-13 Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing Kurimoto, Noriyuki Nishida, Yu Hosomi, Shuhei Itani, Shigehiro Kobayashi, Yumie Nakata, Rieko Ominami, Masaki Nadatani, Yuji Fukunaga, Shusei Otani, Koji Tanaka, Fumio Nagami, Yasuaki Taira, Koichi Kamata, Noriko Fujiwara, Yasuhiro PLoS One Research Article Endoscopic mucosal healing (MH) is an important treatment goal for patients with ulcerative colitis (UC). The neutrophil-to-lymphocyte ratio (NLR) reflects systemic inflammation and has been reported to be a useful predictive marker for UC. This study aimed to evaluate the clinical utility of the NLR for predicting clinical relapse in UC patients with MH. We retrospectively enrolled patients with UC who underwent colonoscopy at the Osaka City University Hospital between January 2010 and December 2010, whose Mayo Endoscopic Subscore was 0 or 1. The correlation between the incidence of relapse and demographic factors, including the NLR, was analyzed. We included 129 patients in the present study. The median NLR at the time of endoscopy was 1.98, and differences in the high NLR group and the low NLR group were compared. During a median follow-up period of 46.4 months, 58 patients (45.0%) experienced relapse. The cumulative relapse-free rate was significantly higher in the low NLR group than in the high NLR group (P = 0.03, log-rank test). Multivariate analysis identified high NLR as an independent prognostic factor for clinical relapse (hazard ratio, 1.74; 95% confidence interval, 1.02–2.98; P = 0.04). NLR is a novel and useful predictor of clinical relapse in UC patients with MH, and it can potentially be a strong indicator to determine the appropriate treatment strategy and decision-making in clinical practice. Public Library of Science 2023-01-12 /pmc/articles/PMC9836288/ /pubmed/36634124 http://dx.doi.org/10.1371/journal.pone.0280252 Text en © 2023 Kurimoto et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Kurimoto, Noriyuki
Nishida, Yu
Hosomi, Shuhei
Itani, Shigehiro
Kobayashi, Yumie
Nakata, Rieko
Ominami, Masaki
Nadatani, Yuji
Fukunaga, Shusei
Otani, Koji
Tanaka, Fumio
Nagami, Yasuaki
Taira, Koichi
Kamata, Noriko
Fujiwara, Yasuhiro
Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
title Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
title_full Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
title_fullStr Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
title_full_unstemmed Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
title_short Neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
title_sort neutrophil-to-lymphocyte ratio may predict clinical relapse in ulcerative colitis patients with mucosal healing
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836288/
https://www.ncbi.nlm.nih.gov/pubmed/36634124
http://dx.doi.org/10.1371/journal.pone.0280252
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