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Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study rec...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836295/ https://www.ncbi.nlm.nih.gov/pubmed/36634101 http://dx.doi.org/10.1371/journal.pone.0280136 |
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author | Si, Lining Wang, Haiyuan Wang, Rong Tsering, Lhachen Long, Qifu Jiang, Yahui Yi, Yun Zhao, Yanli |
author_facet | Si, Lining Wang, Haiyuan Wang, Rong Tsering, Lhachen Long, Qifu Jiang, Yahui Yi, Yun Zhao, Yanli |
author_sort | Si, Lining |
collection | PubMed |
description | High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study recruited 238 patients with HAPE and 230 healthy controls in Northwest China. Genomic DNA was extracted from blood samples, and gene polymorphisms were detected using the Agena MassARRAY platform. Odds ratios (ORs), 95% confidence intervals (95% CIs), and P-value were used to evaluate the relationship between HAPE risk and CYP4F2 gene polymorphisms. Multi-factor dimension reduction (MDR) was used to assess the optimal interaction of CYP4F2 gene polymorphisms on HAPE risk. We found rs3093193 was shown to reduce the risk of HAPE (OR = 0.70, 95% CI = 0.52–0.93, P = 0.014), while rs12459936 was increased the susceptibility to HAPE (OR = 2.08, 95% CI = 1.33–3.26, P = 0.001). Age stratified analysis revealed that rs3093193 and rs12459936 were correlated with HAPE risk in people at age > 32 years old, and rs3093193 and rs3093110 were correlated with the HAPE risk in people at age ≤ 32 years old. Gender stratification analysis was found that rs3093193, rs12459936, and rs3093110 were all related to HAPE risk in males. A combination of rs12459936 and rs3093110 was the best multi-loci model with the highest testing accuracy. Our study is the first to provide the association between CYP4F2 gene polymorphisms and HAPE risk in the Chinese Han population. |
format | Online Article Text |
id | pubmed-9836295 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-98362952023-01-13 Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population Si, Lining Wang, Haiyuan Wang, Rong Tsering, Lhachen Long, Qifu Jiang, Yahui Yi, Yun Zhao, Yanli PLoS One Research Article High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study recruited 238 patients with HAPE and 230 healthy controls in Northwest China. Genomic DNA was extracted from blood samples, and gene polymorphisms were detected using the Agena MassARRAY platform. Odds ratios (ORs), 95% confidence intervals (95% CIs), and P-value were used to evaluate the relationship between HAPE risk and CYP4F2 gene polymorphisms. Multi-factor dimension reduction (MDR) was used to assess the optimal interaction of CYP4F2 gene polymorphisms on HAPE risk. We found rs3093193 was shown to reduce the risk of HAPE (OR = 0.70, 95% CI = 0.52–0.93, P = 0.014), while rs12459936 was increased the susceptibility to HAPE (OR = 2.08, 95% CI = 1.33–3.26, P = 0.001). Age stratified analysis revealed that rs3093193 and rs12459936 were correlated with HAPE risk in people at age > 32 years old, and rs3093193 and rs3093110 were correlated with the HAPE risk in people at age ≤ 32 years old. Gender stratification analysis was found that rs3093193, rs12459936, and rs3093110 were all related to HAPE risk in males. A combination of rs12459936 and rs3093110 was the best multi-loci model with the highest testing accuracy. Our study is the first to provide the association between CYP4F2 gene polymorphisms and HAPE risk in the Chinese Han population. Public Library of Science 2023-01-12 /pmc/articles/PMC9836295/ /pubmed/36634101 http://dx.doi.org/10.1371/journal.pone.0280136 Text en © 2023 Si et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Si, Lining Wang, Haiyuan Wang, Rong Tsering, Lhachen Long, Qifu Jiang, Yahui Yi, Yun Zhao, Yanli Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population |
title | Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population |
title_full | Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population |
title_fullStr | Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population |
title_full_unstemmed | Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population |
title_short | Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population |
title_sort | suggestive evidence of cyp4f2 gene polymorphisms with hape susceptibility in the chinese han population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836295/ https://www.ncbi.nlm.nih.gov/pubmed/36634101 http://dx.doi.org/10.1371/journal.pone.0280136 |
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