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Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population

High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study rec...

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Autores principales: Si, Lining, Wang, Haiyuan, Wang, Rong, Tsering, Lhachen, Long, Qifu, Jiang, Yahui, Yi, Yun, Zhao, Yanli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836295/
https://www.ncbi.nlm.nih.gov/pubmed/36634101
http://dx.doi.org/10.1371/journal.pone.0280136
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author Si, Lining
Wang, Haiyuan
Wang, Rong
Tsering, Lhachen
Long, Qifu
Jiang, Yahui
Yi, Yun
Zhao, Yanli
author_facet Si, Lining
Wang, Haiyuan
Wang, Rong
Tsering, Lhachen
Long, Qifu
Jiang, Yahui
Yi, Yun
Zhao, Yanli
author_sort Si, Lining
collection PubMed
description High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study recruited 238 patients with HAPE and 230 healthy controls in Northwest China. Genomic DNA was extracted from blood samples, and gene polymorphisms were detected using the Agena MassARRAY platform. Odds ratios (ORs), 95% confidence intervals (95% CIs), and P-value were used to evaluate the relationship between HAPE risk and CYP4F2 gene polymorphisms. Multi-factor dimension reduction (MDR) was used to assess the optimal interaction of CYP4F2 gene polymorphisms on HAPE risk. We found rs3093193 was shown to reduce the risk of HAPE (OR = 0.70, 95% CI = 0.52–0.93, P = 0.014), while rs12459936 was increased the susceptibility to HAPE (OR = 2.08, 95% CI = 1.33–3.26, P = 0.001). Age stratified analysis revealed that rs3093193 and rs12459936 were correlated with HAPE risk in people at age > 32 years old, and rs3093193 and rs3093110 were correlated with the HAPE risk in people at age ≤ 32 years old. Gender stratification analysis was found that rs3093193, rs12459936, and rs3093110 were all related to HAPE risk in males. A combination of rs12459936 and rs3093110 was the best multi-loci model with the highest testing accuracy. Our study is the first to provide the association between CYP4F2 gene polymorphisms and HAPE risk in the Chinese Han population.
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spelling pubmed-98362952023-01-13 Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population Si, Lining Wang, Haiyuan Wang, Rong Tsering, Lhachen Long, Qifu Jiang, Yahui Yi, Yun Zhao, Yanli PLoS One Research Article High altitude pulmonary edema (HAPE) is a common respiratory disease in the high altitude area, which is rapid and harmful. We firstly conducted a case-control study to assess the potential association of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population. The study recruited 238 patients with HAPE and 230 healthy controls in Northwest China. Genomic DNA was extracted from blood samples, and gene polymorphisms were detected using the Agena MassARRAY platform. Odds ratios (ORs), 95% confidence intervals (95% CIs), and P-value were used to evaluate the relationship between HAPE risk and CYP4F2 gene polymorphisms. Multi-factor dimension reduction (MDR) was used to assess the optimal interaction of CYP4F2 gene polymorphisms on HAPE risk. We found rs3093193 was shown to reduce the risk of HAPE (OR = 0.70, 95% CI = 0.52–0.93, P = 0.014), while rs12459936 was increased the susceptibility to HAPE (OR = 2.08, 95% CI = 1.33–3.26, P = 0.001). Age stratified analysis revealed that rs3093193 and rs12459936 were correlated with HAPE risk in people at age > 32 years old, and rs3093193 and rs3093110 were correlated with the HAPE risk in people at age ≤ 32 years old. Gender stratification analysis was found that rs3093193, rs12459936, and rs3093110 were all related to HAPE risk in males. A combination of rs12459936 and rs3093110 was the best multi-loci model with the highest testing accuracy. Our study is the first to provide the association between CYP4F2 gene polymorphisms and HAPE risk in the Chinese Han population. Public Library of Science 2023-01-12 /pmc/articles/PMC9836295/ /pubmed/36634101 http://dx.doi.org/10.1371/journal.pone.0280136 Text en © 2023 Si et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Si, Lining
Wang, Haiyuan
Wang, Rong
Tsering, Lhachen
Long, Qifu
Jiang, Yahui
Yi, Yun
Zhao, Yanli
Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
title Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
title_full Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
title_fullStr Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
title_full_unstemmed Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
title_short Suggestive evidence of CYP4F2 gene polymorphisms with HAPE susceptibility in the Chinese Han population
title_sort suggestive evidence of cyp4f2 gene polymorphisms with hape susceptibility in the chinese han population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836295/
https://www.ncbi.nlm.nih.gov/pubmed/36634101
http://dx.doi.org/10.1371/journal.pone.0280136
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