Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles

The direct genetically encoded cell-based synthesis of non-natural peptide and depsipeptide macrocycles is an outstanding challenge. Here we programme the encoded synthesis of 25 diverse non-natural macrocyclic peptides, each containing two non-canonical amino acids, in Syn61Δ3-derived cells; these...

Descripción completa

Detalles Bibliográficos
Autores principales: Spinck, Martin, Piedrafita, Carlos, Robertson, Wesley E., Elliott, Thomas S., Cervettini, Daniele, de la Torre, Daniel, Chin, Jason W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836938/
https://www.ncbi.nlm.nih.gov/pubmed/36550233
http://dx.doi.org/10.1038/s41557-022-01082-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836938/
https://www.ncbi.nlm.nih.gov/pubmed/36550233
http://dx.doi.org/10.1038/s41557-022-01082-0

Ejemplares similares